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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 461989, 15 pages
Mixture of Polyphenols and Anthocyanins from Vaccinium uliginosum L. Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice
Department of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University, 1 Hoegi, Seoul 130-701, Republic of Korea
Received 15 June 2012; Accepted 22 August 2012
Academic Editor: José Luis Ríos
Copyright © 2012 Min Ju Kim and Se-Young Choung. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- D. Y. M. Leung and N. A. Soter, “Cellular and immunologic mechanisms in atopic dermatitis,” Journal of the American Academy of Dermatology, vol. 44, no. 1, pp. S1–S12, 2001.
- E. Guttman-Yassky, M. A. Lowes, J. Fuentes-Duculan et al., “Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis,” The Journal of Immunology, vol. 181, no. 10, pp. 7420–7427, 2008.
- Y. H. Kim, C. Y. Bang, E. K. Won, J. P. Kim, and S. Y. Choung, “Antioxidant activities of Vaccinium uliginosum L. extract and its active components,” Journal of Medicinal Food, vol. 12, no. 4, pp. 885–892, 2009.
- J. Y. Bae, S. S. Lim, S. J. Kim et al., “Bog blueberry anthocyanins alleviate photoaging in ultraviolet-B irradiation-induced human dermal fibroblasts,” Molecular Nutrition and Food Research, vol. 53, no. 6, pp. 726–738, 2009.
- G. S. Jensen, X. Wu, K. M. Patterson et al., “In vitro and in vivo antioxidant and anti-inflammatory capacities of an antioxidant-rich fruit and berry juice blend. Results of a pilot and randomized, double-blinded, placebo-controlled, crossover study,” Journal of Agricultural and Food Chemistry, vol. 56, no. 18, pp. 8326–8333, 2008.
- H. Jin, et al., “Animal models of atopic dermatitis,” The Journal of Allergy and Clinical Immunology, vol. 111, no. 2, pp. 486–494, 2003.
- E. Galli, R. Cicconi, P. Rossi, A. Casati, E. Brunetti, and G. Mancino, “Atopic dermatitis: molecular mechanism, clinical aspects and new therapeutical approaches,” Current Molecular Medicine, vol. 3, no. 2, pp. 127–138, 2003.
- S. J. Lee, S. G. Oh, S. W. Seo et al., “Oral administration of Astragalus membranaceus inhibits the development of DNFB-induced dermatitis in NC/Nga mice,” Biological and Pharmaceutical Bulletin, vol. 30, no. 8, pp. 1468–1471, 2007.
- H. Jin, R. He, M. Oyoshi, and R. S. Geha, “Animal models of atopic dermatitis,” Journal of Investigative Dermatology, vol. 129, no. 1, pp. 31–40, 2009.
- K. Hattori, M. Nishikawa, K. Watcharanurak et al., “Sustained exogenous expression of therapeutic levels of IFN-γ ameliorates atopic dermatitis in NC/Nga mice via Th1 polarization,” The Journal of Immunology, vol. 184, no. 5, pp. 2729–2735, 2010.
- A. Grassegger and R. Höpfl, “Significance of the cytokine interferon gamma in clinical dermatology,” Clinical and Experimental Dermatology, vol. 29, no. 6, pp. 584–588, 2004.
- G. Toldi, A. Molvarec, B. Stenczer et al., “Peripheral 1/2/17/regulatory T-cell balance in asthmatic pregnancy,” International Immunology, vol. 23, no. 11, pp. 669–677, 2011.
- A. D. Cesare, P. D. Meglio, and F. O. Nestle, “A role for Th17 cells in the immunopathogenesis of atopic dermatitis?” Journal of Investigative Dermatology, vol. 128, no. 11, pp. 2569–2571, 2008.
- V. S. Beltrani, “Suggestions regarding a more appropriate understanding of atopic dermatitis,” Current Opinion in Allergy and Clinical Immunology, vol. 5, no. 5, pp. 413–418, 2005.
- D. Rudikoff and M. Lebwohl, “Atopic dermatitis,” The Lancet, vol. 351, no. 9117, pp. 1715–1721, 1998.
- T. B. Donald and Y. M. Leung, Atopic Dermatitis, Marcel Dekker, 2002.
- M. Furue, H. Terao, W. Rikihisa et al., “Clinical dose and adverse effects of topical steroids in daily management of atopic dermatitis,” British Journal of Dermatology, vol. 148, no. 1, pp. 128–133, 2003.
- S. Valtueña, D. Del Rio, N. Pellegrini et al., “The total antioxidant capacity of the diet is an independent predictor of plasma β-carotene,” European Journal of Clinical Nutrition, vol. 61, no. 1, pp. 69–76, 2007.
- S. Y. Wang and H. S. Lin, “Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage,” Journal of Agricultural and Food Chemistry, vol. 48, no. 2, pp. 140–146, 2000.
- T. M. Collantes, M.-C. Rho, H.-J. Kwon et al., “Azuki bean (Vigna angularis) extract inhibits the development of experimentally induced atopic dermatitis-like skin lesions in NC/Nga mice,” Food Chemistry, vol. 132, no. 3, pp. 1269–1275, 2012.
- H. S. Lee, S. K. Kim, J. B. Han et al., “Inhibitory effects of Rumex japonicus Houtt. on the development of atopic dermatitis-like skin lesions in NC/Nga mice,” British Journal of Dermatology, vol. 155, no. 1, pp. 33–38, 2006.
- T. Inoue, M. Sugimoto, T. Sakurai et al., “Modulation of scratching behavior by silencing an endogenous cyclooxygenase-1 gene in the skin through the administration of siRNA,” Journal of Gene Medicine, vol. 9, no. 11, pp. 994–1001, 2007.
- T. Maekawa, T. Yamaguchi-Miyamoto, H. Nojima, and Y. Kuraishi, “Effects of naltrexone on spontaneous itch-associated responses in NC mice with chronic dermatitis,” Japanese Journal of Pharmacology, vol. 90, no. 2, pp. 193–196, 2002.
- N. Takano, I. Arai, and M. Kurachi, “Analysis of the spontaneous scratching behavior by NC/Nga mice: a possible approach to evaluate antipruritics for subjects with atopic dermatitis,” European Journal of Pharmacology, vol. 471, no. 3, pp. 223–228, 2003.
- S. Park, J. B. Lee, and S. Kang, “Topical application of Chrysanthemum indicum L. Attenuates the development of atopic dermatitis-like skin lesions by suppressing serum IgE levels, IFN-γ , and IL-4 in Nc/Nga mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 821967, 8 pages, 2012.
- K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the method,” Methods, vol. 25, no. 4, pp. 402–408, 2001.
- H. C. Williams, “Epidemiology of atopic dermatitis,” Clinical and Experimental Dermatology, vol. 25, no. 7, pp. 522–529, 2000.
- C. Flohr, “Atopic dermatitis diagnostic criteria and outcome measures for clinical trials: still a mess,” Journal of Investigative Dermatology, vol. 131, no. 3, pp. 557–559, 2011.
- J. H. Choi, B. H. Park, H. G. Kim et al., “Inhibitory effect of Psidium guajava water extract in the development of 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice,” Food and Chemical Toxicology, vol. 50, no. 8, pp. 2923–2929, 2012.
- J. F. Fowler Jr., H. Woolery-Lloyd, H. Waldorf, and R. Saini, “Innovations in natural ingredients and their use in skin care,” Journal of Drugs in Dermatology, vol. 9, no. 6, pp. S72–S82, 2010.
- E. Middleton, C. Kandaswami, and T. C. Theoharides, “The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer,” Pharmacological Reviews, vol. 52, no. 4, pp. 673–751, 2000.
- C. A. Williams and R. J. Grayer, “Anthocyanins and other flavonoids,” Natural Product Reports, vol. 21, no. 4, pp. 539–573, 2004.
- H. Suto, H. Matsuda, K. Mitsuishi et al., “NC/Nga mice: a mouse model for atopic dermatitis,” International Archives of Allergy and Immunology, vol. 120, supplement 1, pp. 70–75, 1999.
- M. Yamamoto, T. Haruna, K. Yasui et al., “A novel atopic dermatitis model induced by topical application with Dermatophagoides farinae extract in NC/Nga mice,” Allergology International, vol. 56, no. 2, pp. 139–148, 2007.
- T. Kawakami, T. Ando, M. Kimura, B. S. Wilson, and Y. Kawakami, “Mast cells in atopic dermatitis,” Current Opinion in Immunology, vol. 21, no. 6, pp. 666–678, 2009.
- R. K. Kumar, C. Herbert, M. Yang, A. M. L. Koskinen, A. N. J. McKenzie, and P. S. Foster, “Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma,” Clinical and Experimental Allergy, vol. 32, no. 7, pp. 1104–1111, 2002.
- I. Carmi-Levy, B. Homey, and V. Soumelis, “A modular view of cytokine networks in atopic dermatitis,” Clinical Reviews in Allergy and Immunology, vol. 41, no. 3, pp. 245–253, 2011.
- D. Y. M. Leung and T. Bieber, “Atopic dermatitis,” The Lancet, vol. 361, no. 9352, pp. 151–160, 2003.
- M. Toda, D. Y. M. Leung, S. Molet et al., “Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions,” Journal of Allergy and Clinical Immunology, vol. 111, no. 4, pp. 875–881, 2003.
- T. Bieber, “Atopic dermatitis,” The New England Journal of Medicine, vol. 358, no. 14, pp. 1483–1430, 2008.
- M. Grewe, K. Gyufko, E. Schopf, and J. Krutman, “Lesional expression of interferon-γ in atopic eczema,” The Lancet, vol. 343, no. 8888, pp. 25–26, 1994.
- T. Werfel, A. Morita, M. Grewe et al., “Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis,” Journal of Investigative Dermatology, vol. 107, no. 6, pp. 871–876, 1996.
- T. Thepen, E. G. Langeveld-Wildschut, I. C. Bihari et al., “Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial response to a response in situ: an immunocytochemical study,” Journal of Allergy and Clinical Immunology, vol. 97, no. 3, pp. 828–837, 1996.
- N. Novak, R. Valenta, B. Bohle et al., “FcεRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro,” Journal of Allergy and Clinical Immunology, vol. 113, no. 5, pp. 949–957, 2004.
- M. L. Giustizieri, F. Mascia, A. Frezzolini et al., “Keratinocytes from patients with atopic dermatitis and psoriasis show a distinct chemokine production profile in response to T cell-derived cytokines,” Journal of Allergy and Clinical Immunology, vol. 107, no. 5, pp. 871–877, 2001.
- C. T. Weaver, R. D. Hatton, P. R. Mangan, and L. E. Harrington, “IL-17 family cytokines and the expanding diversity of effector T cell lineages,” Annual Review of Immunology, vol. 25, pp. 821–852, 2007.
- I. Böhm and R. Bauer, “Th1-cells, Th2-cells and atopic dermatitis,” Hautarzt, vol. 48, no. 4, pp. 223–227, 1997.
- S. Romagnani, “Immunologic influences on allergy and the 1/2 balance,” Journal of Allergy and Clinical Immunology, vol. 113, no. 3, pp. 395–400, 2004.
- A. P. Mountford, A. Fisher, and R. A. Wilson, “The profile of IgG1 and IgG2a antibody responses in mice exposed to Schistosoma mansoni,” Parasite Immunology, vol. 16, no. 10, pp. 521–527, 1994.
- C. S. Koblenzer, “Itching and the atopic skin,” Journal of Allergy and Clinical Immunology, vol. 104, no. 3, pp. S109–S113, 1999.
- C. F. Wahlgren, “Itch and atopic dermatitis: an overview,” Journal of Dermatology, vol. 26, no. 11, pp. 770–779, 1999.
- Q. Hamid, M. Boguniewicz, and D. Y. M. Leung, “Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis,” The Journal of Clinical Investigation, vol. 94, no. 2, pp. 870–876, 1994.
- A. B. Kay, S. Ying, V. Varney et al., “Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects,” Journal of Experimental Medicine, vol. 173, no. 3, pp. 775–778, 1991.
- Y. Tanaka, E. Delaporte, S. Dubucquoi et al., “Interleukin-5 messenger RNA and immunoreactive protein expression by activated eosinophils in lesional atopic dermatitis skin,” Journal of Investigative Dermatology, vol. 103, no. 4, pp. 589–592, 1994.
- S. Ying, D. S. Robinson, Q. Meng et al., “Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells,” European Journal of Immunology, vol. 27, no. 12, pp. 3507–3516, 1997.
- E. Bettelli, M. Oukka, and V. K. Kuchroo, “-17 cells in the circle of immunity and autoimmunity,” Nature Immunology, vol. 8, no. 4, pp. 345–350, 2007.
- L. Steinman, “A brief history of 17, the first major revision in the 1/2 hypothesis of T cell-mediated tissue damage,” Nature Medicine, vol. 13, no. 2, pp. 139–145, 2007.
- C. Koga, K. Kabashima, N. Shiraishi, M. Kobayashi, and Y. Tokura, “Possible pathogenic role of Th17 cells for atopic dermatitis,” Journal of Investigative Dermatology, vol. 128, no. 11, pp. 2625–2630, 2008.
- Y. Souwer, K. Szegedi, M. L. Kapsenberg, and E. C. De Jong, “IL-17 and IL-22 in atopic allergic disease,” Current Opinion in Immunology, vol. 22, no. 6, pp. 821–826, 2010.