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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 464586, 10 pages
http://dx.doi.org/10.1155/2012/464586
Research Article

Therapeutic Effects of Acupuncture through Enhancement of Functional Angiogenesis and Granulogenesis in Rat Wound Healing

1Institute of Catholic Integrative Medicine (ICIM), Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon 403-720, Republic of Korea
2Department of Radiology, Incheon St. Mary’s Hospital, The Catholic University of Korea, Incheon, Republic of Korea
3Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, USA
4Department of Radiology, St. Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of Korea

Received 27 July 2012; Revised 8 November 2012; Accepted 14 November 2012

Academic Editor: Wolfgang Schwarz

Copyright © 2012 Sang In Park et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. J. Singer and R. A. F. Clark, “Cutaneous wound healing,” New England Journal of Medicine, vol. 341, no. 10, pp. 738–746, 1999. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Chodorowska and D. Roguś-Skorupska, “Cutaneous wound healing.,” Annales Universitatis Mariae Curie-Sklodowska. Sectio D, vol. 59, no. 2, pp. 403–407, 2004. View at Scopus
  3. S. C. Heo, E. S. Jeon, I. H. Lee, H. S. Kim, M. B. Kim, and J. H. Kim, “Tumor necrosis factor-α-activated human adipose tissue-derived mesenchymal stem cells accelerate cutaneous wound healing through paracrine mechanisms,” Journal of Investigative Dermatology, vol. 131, no. 7, pp. 1559–1567, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. R. L. Eckert, T. Efimova, S. R. Dashti et al., “Keratinocyte survival, differentiation, and death: many roads lead to mitogen-activated protein kinase,” Journal of Investigative Dermatology Symposium Proceedings, vol. 7, no. 1, pp. 36–40, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Schauber, R. A. Dorschner, A. B. Coda et al., “Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism,” Journal of Clinical Investigation, vol. 117, no. 3, pp. 803–811, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. E. M. Conway, D. Collen, and P. Carmeliet, “Molecular mechanisms of blood vessel growth,” Cardiovascular Research, vol. 49, no. 3, pp. 507–521, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Bitto, L. Minutoli, M. R. Galeano et al., “Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression,” Clinical Science, vol. 114, no. 11-12, pp. 707–718, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. P. Bao, A. Kodra, M. Tomic-Canic, M. S. Golinko, H. P. Ehrlich, and H. Brem, “The role of vascular endothelial growth factor in wound healing,” Journal of Surgical Research, vol. 153, no. 2, pp. 347–358, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Kimura, N. Shibahara, H. Hikiami et al., “Traditional Japanese formula kigikenchuto accelerates healing of pressure-loading skin ulcer in rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 592791, 13 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. M. S. Park, Y. Y. Sunwoo, K. S. Jang et al., “Changes in brain FDG metabolism induced by acupuncture in healthy volunteers,” Acta Radiologica, vol. 51, no. 8, pp. 947–952, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Braddock, C. J. Campbell, and D. Zuder, “Current therapies for wound healing: electrical stimulation, biological therapeutics, and the potential for gene therapy,” International Journal of Dermatology, vol. 38, no. 11, pp. 808–817, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. Z. H. Sun and C. X. Feng, “The clinical observation on acupuncture at Xuanzhong (GB 39) and Ashi points for treatment of orthopedic postoperative pain,” Zhongguo Zhen Jiu, vol. 27, no. 12, pp. 895–897, 2007. View at Scopus
  13. J. A. Lee, H. J. Jeong, H. J. Park, S. Jeon, and S. U. Hong, “Acupuncture accelerates wound healing in burn-injured mice,” Burns, vol. 37, no. 1, pp. 117–125, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Nakajima, M. Inoue, T. Hojo et al., “Effect of electroacupuncture on the healing process of tibia fracture in a rat model: a randomised controlled trial,” Acupuncture in Medicine, vol. 28, no. 3, pp. 140–143, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Kiwanuka, J. Junker, and E. Eriksson, “Harnessing growth factors to influence wound healing,” Clinics in Plastic Surgery, vol. 39, no. 3, pp. 239–248, 2012.
  16. N. N. Nissen, P. J. Polverini, A. E. Koch, M. V. Volin, R. L. Gamelli, and L. A. DiPietro, “Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing,” American Journal of Pathology, vol. 152, no. 6, pp. 1445–1452, 1998. View at Scopus
  17. M. Gaudry, O. Brégerie, V. Andrieu, J. El Benna, M. A. Pocidalo, and J. Hakim, “Intracellular pool of vascular endothelial growth factor in human neutrophils,” Blood, vol. 90, no. 10, pp. 4153–4161, 1997. View at Scopus
  18. F. J. Zijlstra, I. van den Berg-de Lange, F. J. P. M. Huygen, and J. Klein, “Anti-inflammatory actions of acupuncture,” Mediators of Inflammation, vol. 12, no. 2, pp. 59–69, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Aoki, T. Kasahara, H. Hagiwara, M. Sunaga, N. Hisamitsu, and T. Hisamitsu, “Electroacupuncture and moxibustion influence the lipopolysaccharide-induced TNF-α production by macrophages,” In Vivo, vol. 19, no. 3, pp. 495–500, 2005. View at Scopus
  20. C. C. Finnerty, D. N. Herndon, R. Przkora et al., “Cytokine expression profile over time in severely burned pediatric patients,” Shock, vol. 26, no. 1, pp. 13–19, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. E. M. C. Sant'Ana, C. M. C. P. Gouvêa, J. L. Q. Durigan, M. R. Cominetti, E. R. Pimentel, and H. S. Selistre-de-Araújo, “Rat skin wound healing induced by alternagin-C, a disintegrin-like, Cys-rich protein from Bothrops alternatus venom,” International Wound Journal, vol. 8, no. 3, pp. 245–252, 2011. View at Publisher · View at Google Scholar · View at Scopus