Impact of Global Normalization in fMRI Acupuncture Studies

Table 1

Comparison of Number of Activation/Deactivation for NO PSGS and PSGS.

			Acupuncture								Tactile
Subjects no.		Num. of activations			Num. of deactivations			Subjects no.		Num. of activations			Num. of deactivations
		NO PSGS	PSGS	▵	NO PSGS	PSGS	▵			NO PSGS	PSGS	▵	NO PSGS	PSGS	▵
Sub01		5955	3859	−35%	2418	2258	-7%	Sub01		137	493	260%	1858	776	−58%
Sub02		5331	4335	−19%	1224	3183	160%	Sub02		1011	4591	354%	3763	2024	−46%
Sub03		8858	1681	−81%	23	7094	30743%	Sub03		5458	2861	−48%	119	2089	1655%
Sub04		2067	2056	−1%	8	48	500%	Sub04		4598	2929	−36%	122	1269	940%
Sub05		1514	882	−42%	15	516	3340%	Sub05		669	1160	73%	391	285	−27%
Sub06		1	31	3000%	407	112	−72%	Sub06		3028	2299	−24%	634	1480	133%
Sub07		429	426	−1%	933	666	−29%	Sub07		556	1506	171%	2005	1964	−2%
Sub08		8109	2422	−70%	18	2430	13400%	Sub08		10999	3706	−66%	49	10182	20680%
Sub09		640	1017	59%	61	71	16%	Sub09		7024	5328	−24%	2556	5031	97%
Sub10		9388	3007	−68%	3095	9423	204%	Sub10		2294	917	−60%	1	527	52600%
Sub11		1588	1191	−25%	447	924	107%	Sub11		5969	5084	−15%	2746	4033	47%
Sub12		3866	5659	46%	2090	3682	76%	Sub12		1854	1528	−18%	11	462	4100%
Sub13		39	6694	17064%	13037	2450	−81%	Sub13		546	499	−9%	19	75	295%
Sub14		228	896	293%	7	20	186%	Sub14		151	1306	765%	2027	1446	−29%
Sub15		5261	1849	−65%	381	1260	231%	Sub15		2200	685	−69%	26	164	531%
Sub16		278	358	29%	583	441	−24%	Sub16		9497	3009	−68%	813	3679	353%
Sub17		1043	693	−34%	138	574	316%	Sub17		1562	908	−42%	268	674	151%
Sub18		5043	1906	−62%	552	1863	238%	Sub18		9705	1959	−80%	0	5181	Inf
Sub19		1556	2972	91%	6238	4362	−30%	Sub19		2072	4972	140%	7039	2554	−64%
Sub20		6001	2295	−62%	684	1831	168%	Sub20		116	849	632%	227	308	36%
Sub21		360	1157	221%	2715	580	−79%	Sub21		1975	1787	−10%	530	797	50%
Sub22		570	480	−16%	1	6	500%	Sub22		8714	4877	−44%	1112	3986	258%
Mean		3097	2085	−33%	1594	1991	25%	Sub23		1039	1478	42%	1052	1183	12%
								Mean		3529	2380	−33%	1190	2181	83%
	P < 0.00001	850	1350	59%	59	245	315%		P < 0.00001	2231	902	−60%	87	1486	1608%
Group	P < 0.001	5831	4680	−20%	821	4722	475%	Group	P < 0.001	8505	3509	−59%	2252	7520	234%
	P < 0.01	21067	7953	−34%	3521	11687	232%		P < 0.01	14955	6401	−57%	6098	14016	130%

The activations and deactivations are thresholded at 𝑃<0.00001, uncorrected. ▵>100% are shown in bold and colored in red (activations) or light blue (deactivations). ▵<−50% are shown in bold and colored in orange (activations) or green (deactivations). Abbreviations: ▵: (PSGS − NO PSGS)/NO PSGS*100%.