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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 473637, 25 pages
http://dx.doi.org/10.1155/2012/473637
Review Article

Boesenbergia rotunda: From Ethnomedicine to Drug Discovery

1Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
2Drug Design and Development Research Group (DDDRG), University of Malaya, 50603 Kuala Lumpur, Malaysia
3Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
4Division of Pharmacy, School of Pharmacy and Health Sciences, International Medical University (IMU), Bukit Jalil, 57000 Kuala Lumpur, Malaysia
5Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
6Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
7Biotechnology and Bioproduct Research Cluster (UMBIO), University of Malaya, 50603 Kuala Lumpur, Malaysia

Received 26 June 2012; Accepted 6 August 2012

Academic Editor: Y. Ohta

Copyright © 2012 Tan Eng-Chong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Boesenbergia rotunda is a herb from the Boesenbergia genera under the Zingiberaceae family. B. rotunda is widely found in Asian countries where it is commonly used as a food ingredient and in ethnomedicinal preparations. The popularity of its ethnomedicinal usage has drawn the attention of scientists worldwide to further investigate its medicinal properties. Advancement in drug design and discovery research has led to the development of synthetic drugs from B. rotunda metabolites via bioinformatics and medicinal chemistry studies. Furthermore, with the advent of genomics, transcriptomics, proteomics, and metabolomics, new insights on the biosynthetic pathways of B. rotunda metabolites can be elucidated, enabling researchers to predict the potential bioactive compounds responsible for the medicinal properties of the plant. The vast biological activities exhibited by the compounds obtained from B. rotunda warrant further investigation through studies such as drug discovery, polypharmacology, and drug delivery using nanotechnology.