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- Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 479016, 10 pages
Red Ginseng Extract Attenuates Kainate-Induced Excitotoxicity by Antioxidative Effects
1Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea
2College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea
3College of Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea
4College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea
Received 17 April 2012; Revised 11 September 2012; Accepted 20 September 2012
Academic Editor: Paul Siu-Po Ip
Copyright © 2012 Jin-Yi Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- R. J. Ko, “Adulterants in Asian patent medicines,” The New England Journal of Medicine, vol. 339, no. 12, p. 847, 1998.
- N. R. Slifman, W. R. Obermeyer, B. K. Aloi et al., “Contamination of botanical dietary supplements by Digitalis lanata,” The New England Journal of Medicine, vol. 339, no. 12, pp. 806–811, 1998.
- T. K. Yun, “Brief introduction of Panax ginseng C.A. Meyer,” Journal of Korean Medical Science, vol. 16, supplement, pp. S3–S5, 2001.
- K. S. Kang, H. Y. Kim, S. H. Baek, H. H. Yoo, J. H. Park, and T. Yokozawa, “Study on the hydroxyl radical scavenging activity changes of ginseng and ginsenoside-Rb2 by heat processing,” Biological and Pharmaceutical Bulletin, vol. 30, no. 4, pp. 724–728, 2007.
- C. A. Rice-Evans, N. J. Miller, and G. Paganga, “Structure-antioxidant activity relationships of flavonoids and phenolic acids,” Free Radical Biology and Medicine, vol. 20, no. 7, pp. 933–956, 1996.
- E. J. Lien, S. Ren, H. H. Bui, and R. Wang, “Quantitative structure-activity relationship analysis of phenolic antioxidants,” Free Radical Biology and Medicine, vol. 26, no. 3-4, pp. 285–294, 1999.
- S. Son and B. A. Lewis, “Free radical scavenging and antioxidative activity of caffeic acid amide and ester analogues: structure-activity relationship,” Journal of Agricultural and Food Chemistry, vol. 50, no. 3, pp. 468–472, 2002.
- W. Zheng and S. Y. Wang, “Antioxidant activity and phenolic compounds in selected herbs,” Journal of Agricultural and Food Chemistry, vol. 49, no. 11, pp. 5165–5170, 2001.
- N. Nakatani, “Phenolic antioxidants from herbs and spices,” BioFactors, vol. 13, no. 1–4, pp. 141–146, 2000.
- A. S. Attele, J. A. Wu, and C. S. Yuan, “Ginseng pharmacology: multiple constituents and multiple actions,” Biochemical Pharmacology, vol. 58, no. 11, pp. 1685–1693, 1999.
- H. Kaneko and K. Nakanishi, “Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, Korean red ginseng: specifically its anti-stress action for prevention of disease,” Journal of Pharmacological Sciences, vol. 95, no. 2, pp. 158–162, 2004.
- H. Nishijo, T. Uwano, Y. M. Zhong, and T. Ono, “Proof of the mysterious efficacy of ginseng: basic and clinical trials: effects of red ginseng of learning and memory deficits in an animal model of amnesia,” Journal of Pharmacological Sciences, vol. 95, no. 2, pp. 145–152, 2004.
- B. M. Lee, S. K. Lee, and H. S. Kim, “Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, beta-carotene and red ginseng),” Cancer Letters, vol. 132, no. 1-2, pp. 219–227, 1998.
- R. Zhao and W. F. McDaniel, “Ginseng improves strategic learning by normal and brain-damaged rats,” NeuroReport, vol. 9, no. 7, pp. 1619–1624, 1998.
- A. Akaike, H. Katsuki, T. Kume, and T. Maeda, “Reactive oxygen species in NMDA receptor-mediated glutamate neurotoxicity,” Parkinsonism and Related Disorders, vol. 5, no. 4, pp. 203–207, 1999.
- D. W. Choi, “Glutamate neurotoxicity and diseases of the nervous system,” Neuron, vol. 1, no. 8, pp. 623–634, 1988.
- J. W. Ferkany, R. Zaczek, and J. T. Coyle, “Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors,” Nature, vol. 298, no. 5876, pp. 757–759, 1982.
- W. Liu, R. Liu, J. T. Chun et al., “Kainate excitotoxicity in organotypic hippocampal slice cultures: evidence for multiple apoptotic pathways,” Brain Research, vol. 916, no. 1-2, pp. 239–248, 2001.
- S. M. Rothman, “The neurotoxicity of excitatory amino acids is produced by passive chloride influx,” Journal of Neuroscience, vol. 5, no. 6, pp. 1483–1489, 1985.
- J. W. Olney, M. T. Price, L. Samson, and J. Labruyere, “The role of specific ions in glutamate neurotoxicity,” Neuroscience Letters, vol. 65, no. 1, pp. 65–71, 1986.
- M. Hartmann, R. Heumann, and V. Lessmann, “Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses,” The EMBO Journal, vol. 20, no. 21, pp. 5887–5897, 2001.
- R. Koyama and Y. Ikegaya, “Mossy fiber sprouting as a potential therapeutic target for epilepsy,” Current Neurovascular Research, vol. 1, no. 1, pp. 3–10, 2004.
- P. Jenner, “Oxidative damage in neurodegenerative disease,” The Lancet, vol. 344, no. 8925, pp. 796–798, 1994.
- L. P. Liang, M. E. Beaudoin, M. J. Fritz, R. Fulton, and M. Patel, “Kainate-induced seizures, oxidative stress and neuronal loss in aging rats,” Neuroscience, vol. 147, no. 4, pp. 1114–1118, 2007.
- K. Xu and J. L. Stringer, “Antioxidants and free radical scavengers do not consistently delay seizure onset in animal models of acute seizures,” Epilepsy and Behavior, vol. 13, no. 1, pp. 77–82, 2008.
- A. Y. Sun, Y. Cheng, Q. Bu, and F. Oldfield, “The biochemical mechanisms of the excitotoxicity of kainic acid: free radical formation,” Molecular and Chemical Neuropathology, vol. 17, no. 1, pp. 51–63, 1992.
- T. Masumizu, Y. Noda, A. Mori, and L. Packer, “Electron spin resonance assay of ascorbyl radical generation in mouse hippocampal slices during and after kainate-induced seizures,” Brain Research Protocols, vol. 16, no. 1–3, pp. 65–69, 2005.
- J. Y. Han, K. Takeshita, and H. Utsumi, “Noninvasive detection of hydroxyl radical generation in lung by diesel exhaust particles,” Free Radical Biology and Medicine, vol. 30, no. 5, pp. 516–525, 2001.
- G. M. Rosen and E. J. Rauckman, “Spin trapping of superoxide and hydroxyl radicals,” Methods in Enzymology, vol. 105, pp. 198–209, 1984.
- M. J. Turner and G. M. Rosen, “Spin trapping of superoxide and hydroxyl radicals with substituted pyrroline 1-oxides,” Journal of Medicinal Chemistry, vol. 29, no. 12, pp. 2439–2444, 1986.
- C. Lesuisse, D. Qiu, C. M. Böse, K. Nakaso, and F. Rupp, “Regulation of agrin expression in hippocampal neurons by cell contact and electrical activity,” Molecular Brain Research, vol. 81, no. 1-2, pp. 92–100, 2000.
- S. Y. Li, J. H. Ni, D. S. Xu, and H. T. Jia, “Down-regulation of GluR2 is associated with Ca2+-dependent protease activities in kainate-induced apoptotic cell death in culturd rat hippocampal neurons,” Neuroscience Letters, vol. 352, no. 2, pp. 105–108, 2003.
- H. Wang and J. A. Joseph, “Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader,” Free Radical Biology and Medicine, vol. 27, no. 5-6, pp. 612–616, 1999.
- T. Suematsu, T. Kamada, and H. Abe, “Serum lipoperoxide level in patients suffering from liver diseases,” Clinica Chimica Acta, vol. 79, no. 1, pp. 267–270, 1977.
- K. Marxen, K. H. Vanselow, S. Lippemeier, R. Hintze, A. Ruser, and U. P. Hansen, “Determination of DPPH radical oxidation caused by methanolic extracts of some microalgal species by linear regression analysis of spectrophotometric measurements,” Sensors, vol. 7, no. 10, pp. 2080–2095, 2007.
- J. T. Coyle and P. Puttfarcken, “Oxidative stress, glutamate, and neurodegenerative disorders,” Science, vol. 262, no. 5134, pp. 689–695, 1993.
- G. R. Buettner and R. P. Mason, “Spin-trapping methods for detecting superoxide and hydroxyl free radicals in vitro and in vivo,” Methods in Enzymology, vol. 186, pp. 127–133, 1990.
- N. Yamabe, J. G. Lee, Y. J. Lee, et al., “The chemical and 1, 1-diphenyl-2-picrylhydrazyl radical scavenging activity changes of ginsenosides Rb1 and Rg1 by malliard reaction,” Journal of Ginseng Research, vol. 35, no. 1, pp. 60–68, 2011.
- J. Y. Han, J. T. Hong, S. Y. Nam, and K. W. Oh, “Evaluation of hydroxyl radical reduction activity of red ginseng extract using ESR spectroscopy,” Journal of Biomedical Research, vol. 13, no. 1, pp. 83–92, 2012.
- Y. Cai, Q. Luo, M. Sun, and H. Corke, “Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer,” Life Sciences, vol. 74, no. 17, pp. 2157–2184, 2004.
- Y. H. Kong, Y. C. Lee, and S. Y. Choi, “Neuroprotecyive and anti-inflammatory effects of phenolic compounds in panax ginseng C. A. Meyer,” Journal of Ginseng Research, vol. 23, no. 2, pp. 111–114, 2009.
- K. S. Kang, H. Y. Kim, J. S. Pyo, and T. Yokozawa, “Increase in the free radical scavenging activity of ginseng by heat-processing,” Biological and Pharmaceutical Bulletin, vol. 29, no. 4, pp. 750–754, 2006.
- B. H. Han, M. H. Park, and Y. N. Han, “Studies on the antioxidant components of korean ginseng(V): the mechanism of antioxidant activity of maltol and phenolic acid,” Korean Biochemistry Journal, vol. 18, pp. 337–340, 1985.
- B. K. Lee, S. Lee, K. Y. Yi, S. E. Yoo, and Y. S. Jung, “KR-33028, a Novel Na+/H+ exchanger-1 inhibitor, attenuates glutamate-induced apoptotic cell death through Maintaining Mitochondrial Function,” Biomolecules & Therapeutics, vol. 19, no. 4, pp. 445–450, 2011.
- G. R. Lewin and Y. A. Barde, “Physiology of the neurotrophins,” Annual Review of Neuroscience, vol. 19, pp. 289–317, 1996.