Hispolon Protects against Acute Liver Damage in the Rat by Inhibiting Lipid Peroxidation, Proinflammatory Cytokine, and Oxidative Stress and Downregulating the Expressions of iNOS, COX-2, and MMP-9

Figure 4

Effect of hispolon on the hepatic antioxidant enzymes (SOD, CAT, and GPx) activities in CCl₄-treated rats. Animals were i.p. treated with hispolon (5, 10, and 20 mg/kg) once daily for consecutive seven days. One hour after the final hispolon treatment, the rats were injected with CCl₄ (1.5 mL/kg, i.p.). The rats were killed 24 h after the CCl₄ injection. Hepatotoxicity was determined by quantifying the hepatic antioxidant enzymes (SOD, CAT, and GPx). The values are reported as the mean ± S.D. of six rats per group. ^###𝑃<0.001, compared with the control group; *𝑃<0.05, **𝑃<0.01, and **𝑃<0.001 compared with the CCl₄ group.

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