Acupuncture Alleviates Colorectal Hypersensitivity and Correlates with the Regulatory Mechanism of TrpV1 and p-ERK
Figure 2
CRD test results before EA. CRD0: responses to colorectal distension in 4 groups before (baseline) saline or zymosan treatment (, ); CRD1: responses to colorectal distension in 4 groups after intracolonic treatment with saline or zymosan (, ) on day 8; CRD2: responses to colorectal distension in 4 groups after intracolonic treatment with saline or zymosan (, , in versus and versus ) on day 10; CRD3: Responses to colon distension in 4 groups after intracolonic treatment with saline or zymosan (, , in versus , versus , versus , and versus ) on day 12. Colorectal hypersensitivity did not develop in saline-treated mice. Data are expressed as percentage (mean ± SEM) of the VMR to colorectal distension on the day of baseline testing (day 4) for each animal and normalized to the response to 60 mm Hg distension (100%) to generate stimulus-response functions.
