Effects and Interaction of Icariin, Curculigoside, and Berberine in Er-Xian Decoction, a Traditional Chinese Medicinal Formula, on Osteoclastic Bone Resorption

Table 1

Effects of I, C, B, and their combination on bone mineral content (BMC) and bone mineral density (BMD) in OVX mice (𝑛=10).

Groups		BMC (mg/mm)			BMD (mg/cm^3)
	Total	Trabecular	Cortical	Total	Trabecular	Cortical
Sham control	1.77 ± 0.27	0.45 ± 0.13	0.89±0.17	500 ± 23	220 ± 25	898±19
OVX control	1.56 ± 0.13	0.33 ± 0.08^ΔΔΔ	0.82±0.13	426 ± 20^ΔΔΔ	114 ± 16^ΔΔΔ	910±19
Nylestriol	1.86 ± 0.21*	0.43 ± 0.04**	0.78±0.14	508 ± 29***	205 ± 20***	916±28
OVX + I (40 mg/kg)	1.67 ± 0.09	0.40 ± 0.08**	0.81±0.16	449 ± 31*	157 ± 25**	906±20
OVX + C (20 mg/kg)	1.62 ± 0.07	0.37 ± 0.09*	0.79±0.12	466 ± 34**	162 ± 30**	885±19
OVX + B (120 mg/kg)	1.56 ± 0.12	0.38 ± 0.11*	0.86±0.15	437 ± 45	149 ± 27**	881±26
OVX + I (40 mg/kg) + C (20 mg/kg) + B (120 mg/kg)	1.52 ± 0.20	0.42 ± 0.05**	0.92±0.17	482 ± 25**	195 ± 22**	889±19

All values are expressed as mean ± SD, ^ΔΔΔ𝑃<0.001 versus sham group; *𝑃<0.05, **𝑃<0.01, ^{* * *}𝑃<0.001 versus OVX group.