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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 497242, 8 pages
http://dx.doi.org/10.1155/2012/497242
Research Article

Assessment of Anticholinesterase Activity of Gelidiella acerosa: Implications for Its Therapeutic Potential against Alzheimer’s Disease

Department of Biotechnology, Alagappa University, Tamil Nadu, Karaikudi 630 003, India

Received 19 August 2012; Revised 8 October 2012; Accepted 25 October 2012

Academic Editor: Andrew Scholey

Copyright © 2012 Arif Nisha Syad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The effect of various solvent extracts of Gelidiella acerosa on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities was investigated. AChE and BuChE inhibitory activities were analyzed by spectrophotometric method. Phytochemical screening of the compounds present in the solvent extracts was done qualitatively. Characterization of the compounds present in the benzene extract of G. acerosa was done by GC-MS analysis. The results showed that, at 487.80 μg/mL, benzene extract showed significant ( ) inhibitory activity against both AChE and BuChE with the percentage of inhibition % (IC50 =  μg/mL) and % (IC50 =  μg/mL), respectively. The mode of inhibition exhibited by benzene extract against the AChE and BuChE was found to be competitive and uncompetitive type of inhibition, respectively. Preliminary phytochemical analysis coupled with GC-MS illustrates that the benzene extract possesses high amount of terpenoids, which could be the reason for potential cholinesterase inhibitory activity.