Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice

Table 2

Effect of UL_EtOH on the concentration (ng/g tissue) of monoamines and their metabolites in the striatum of mice brain.

Groups	Striatum (ng/g tissue)
	NE	MHPG	DA	DOPAC	5-HT	5-HIAA
Normal	408.22±74.25	80.23±84.83	1021.35±74.58	1256.23±160.42	334.60±65.88	242.45±21.90
Control versus FST	331.74±33.07	75.23±45.83	681.62±69.78	927.96±198.73	103.09±44.16^#	140.02±50.36
Imipramine 10 mg/kg	696.74±83.8 **	78.71±17.44	950.93±58.4	1032.17±160.68	426.01±60.75 *	352.37±87.32
ULEtOH 0.125 g/kg	466.40±33.77	61.58±7.65	835.30±92.92	1864.85±272.97 *	241.71±29.87	254.62±36.12
ULEtOH 0.25 g/kg	467.62±24.12	110.10±38.63	735.40±61.14	1873.61±189.68 *	356.64±73.28 *	508.37±43.27 ***
ULEtOH 0.5 g/kg	860.02±67.30 ***	129.91±16.13	743.81±86.79	1847.19±182.61 *	420.20±94.71 *	751.38±34.33 ***

Value were the mean ± SEM (𝑛=6). ^#𝑃<0.05 as compared with the normal group. *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001 as compared with the control group (one-way ANOVA following by Bonferroni’s test).