Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice

Table 3

Effect of UL_EtOH on the concentration (ng/g tissue) of monoamines and their metabolites in the hippocampus of mice brain.

Groups	Hippocampus (ng/g tissue)
	NE	MHPG	DA	DOPAC	5-HT	5-HIAA
Normal	581.57±25.89	640.84±44.27	713.98±27.06	639.43±49.15	638.07±31.74	613.67±78.51
Control versus FST	183.67±24.01^#	210.34±22.72^##	275.21±34.86^##	268.46±26.14	113.72±25.71^###	192.77±15.70^##
Imipramine 10 mg/kg	851.76±96.22 ***	682.1±31.39 ***	633.56±63.63	445.35±94.67	898.71±35.47 ***	1028.46±75.43 ***
ULEtOH 0.125 g/kg	431.38±52.01	386.16±27.86	435.43±63.16	360.87±107.15	201.48±73.29	354.73±91.78
ULEtOH 0.25 g/kg	510.95±52.67 **	515.38±97.48 **	539.59±72.49	432.42±67.79	229.74±55.82	509.97±44.55 *
ULEtOH 0.5 g/kg	824.21±71.69 ***	735.31±.84 ***	612.29±84.59	532.09±42.28	381.89±10.25 **	665.73±42.55 **

Value were the mean ± SEM (𝑛=6). ^#𝑃<0.05, ^##𝑃<0.01, ^###𝑃<0.001 as compared with the normal group.
* 𝑃<0.05,**𝑃<0.01,***𝑃<0.001 as compared with the control group (one-way ANOVA following by Bonferroni’s test).