Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice

Table 4

Effect of UL_EtOH on the concentration (ng/g tissue) of monoamines and their metabolites in the hypothalamus of mice brain.

Groups	Hypothalamus (ng/g tissue)
	NE	MHPG	DA	DOPAC	5-HT	5-HIAA
Normal	162.87±18.84	359.47±42.85	673.24±39.45	632.91±31.21	82.70±1.59	610.04±52.00
Control versus FST	82.12±10.34^#	301.73±33.83	368.95±24.42^##	359.99±20.43	27.61±4.24^###	250.69±51.46^##
Imipramine 10 mg/kg	491.34±17.78 **	750.59±67.95 **	466.00±49.59	498.45±12.95	72.86±5.06 ***	780.53±78.00 ***
ULEtOH 0.125 g/kg	86.59±20.24	256.23±28.26	311.62±49.34	344.75±46.98	37.00±6.16	612.67±65.72 **
ULEtOH 0.25 g/kg	161.51±11.41	357.50±22.94	407.61±23.02	564.04±42.35	40.99±3.46	633.35±65.61 **
ULEtOH 0. 5 g/kg	148.62±13.21	501.39±57.27	439.88±51.01	585.68±26.87	86.84±11.23 ***	877.39±75.70 ***

Value were the means ± SEM (𝑛=6). ^#𝑃<0.05, ^##𝑃<0.01,  ^###𝑃<0.001 as compared with the Normal group.
** 𝑃<0.01,  ***𝑃<0.001 as compared with the control group (one-way ANOVA following by Bonferroni’s test).