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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 506214, 8 pages
Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo
1Department of Pharmacology, School of Pharmacy, Yantai University, Yantai 264005, China
2State Key Laboratory of Long-Acting and Targeting Drug Delivery Technologies, Luye Pharma Group Ltd., Yantai 264003, China
Received 27 May 2012; Revised 23 August 2012; Accepted 13 September 2012
Academic Editor: Seung-Heon Hong
Copyright © 2012 Hongbo Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [12 citations]
The following is the list of published articles that have cited the current article.
- Jing Sun, Peng Guo, Xiaobo Sun, Guibo Sun, Xiangbao Meng, Hongwei Wang, Yun Luo, Meng Qin, Bo Ma, Min Wang, and Dayong Cai, “Isorhamnetin Protects against Doxorubicin-Induced Cardiotoxicity In Vivo and In Vitro,” PLoS ONE, vol. 8, no. 5, 2013.
- Nh Nguyen Huy Thuan, “Recent biotechnological progress in enzymatic synthesis of glycosides,” Journal of Industrial Microbiology & Biotechnology, vol. 40, no. 12, pp. 1329–1356, 2013.
- Hongbo Wang, Pengfei Yu, Jing Bai, Jianqiao Zhang, Liang Kong, Fangxi Zhang, Guangying Du, Shiqian Pei, Lixia Zhang, Yongtao Jiang, Jingwei Tian, and Fenghua Fu, “Ocotillol Enhanced the Antitumor Activity of Doxorubicin via p53-Dependent Apoptosis,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–8, 2013.
- Jing Sun, Guibo Sun, Xiangbao Meng, Hongwei Wang, Min Wang, Meng Qin, Bo Ma, Yun Luo, Yingli Yu, Rongchang Chen, Qidi Ai, and Xiaobo Sun, “Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–12, 2013.
- Daquan Chen, Hongyun Yu, Hongjie Mu, Guisheng Li, and Yan Shen, “Novel multicore niosomes based on double pH-sensitive mixed micelles for Ginsenoside Rh2 delivery,” Artificial Cells Nanomedicine and Biotechnology, vol. 42, no. 3, pp. 205–209, 2014.
- Liang Kong, Jianqiao Zhang, Guohua Yu, Guangyao Lv, Fangxi Zhang, Xiaoguang Chen, Jingwei Tian, and Fenghua Fu, “The pseudoginsenoside F11 ameliorates cisplatin-induced nephrotoxicity without compromising its anti-tumor activity in vivo,” Scientific Reports, vol. 4, 2014.
- Xiaoya Fu, Liang Kong, Mingtan Tang, Jianqiao Zhang, Xueying Zhou, Gang Li, Hongbo Wang, and Fenghua Fu, “Protective effect of ocotillol against doxorubicin-induced acute and chronic cardiac injury,” Molecular Medicine Reports, vol. 9, no. 1, pp. 360–364, 2014.
- Shan Wang, Rui Cai, Junchao Ma, Ting Liu, Xiaoqin Ke, Hong Lu, and Jianjiang Fu, “The natural compound codonolactone impairs tumor induced angiogenesis by downregulating BMP signaling in endothelial cells,” Phytomedicine, vol. 22, no. 11, pp. 1017–1026, 2015.
- Qidi Ai, Guibo Sun, Yun Luo, Xi Dong, Ruifeng Hu, Xiangbao Meng, and Xiaobo Sun, “Ginsenoside Rb1 prevents hypoxia-reoxygenation-induced apoptosis in H9c2 cardiomyocytes via an estrogen receptor-dependent crosstalk among the Akt, JNK, and ERK 1/2 pathways using a label-free quantitative proteomics analysis,” RSC Adv., vol. 5, no. 33, pp. 26346–26363, 2015.
- Hyun-Jung Park, Hyun Soo Shim, Jeom Yong Kim, Joo Young Kim, Sun Kyu Park, and Insop Shim, “Ginseng Purified Dry Extract, BST204, Improved Cancer Chemotherapy-Related Fatigue and Toxicity in Mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, pp. 1–13, 2015.
- El-Sayed M. El-Sayed, Ahmed M. Mansour, and Mohammed S. Abdul-Hameed, “Thymol and Carvacrol Prevent Doxorubicin-Induced Cardiotoxicity by Abrogation of Oxidative Stress, Inflammation, and Apoptosis in Rats,” Journal Of Biochemical And Molecular Toxicology, vol. 30, no. 1, pp. 37–44, 2016.
- Shreesh Ojha, Hasan Al Taee, Sameer Goyal, Umesh B. Mahajan, Chandrgouda R. Patil, D. S. Arya, and Mohanraj Rajesh, “Cardioprotective Potentials of Plant-Derived Small Molecules against Doxorubicin Associated Cardiotoxicity,” Oxidative Medicine and Cellular Longevity, vol. 2016, pp. 1–19, 2016.