Epicatechin Used in the Treatment of Intestinal Inflammatory Disease: An Analysis by Experimental Models
Table 2
Biochemical quantifications of glutathione, myeloperoxidase (MPO), and alkaline phosphatase in the colon of the animals submitted to the acute colitis model.
Glutathione (nmol/g)
MPO (U/g)
Alkaline phosphatase (mU/mg of protein)
Non-colitic
1,555.75 ± 107.83*
16.98 ± 4.63*
8.43 ± 0.79*
TNBS control
954.73 ± 69.74
1,780.19 ± 263.77
17.21 ± 1.16
EC 5
1,035.49 ± 72.95
1,975.90 ± 294.86
20.78 ± 1.98
EC 10
1,176.55 ± 46.34*
1,876.74 ± 243.27
17.83 ± 1.30
EC 25
1,130.95 ± 42.46
1,973.38 ± 178.27
20.04 ± 2.71
EC 50
1,127.25 ± 35.36
1,806.57 ± 219.35
20.47 ± 2.02
Sulfasalazine
1,104.60 ± 22.33
1,814.55 ± 214.46
20.49 ± 2.01
Results are mean ± E.P.M. ANOVA-Dunnet comparing to the TNBS control group, *P < 0.05. n = 5–8. EC 5 to 50: Epicatechin, doses 5 to 50 mg/kg.
