Epicatechin Used in the Treatment of Intestinal Inflammatory Disease: An Analysis by Experimental Models

Table 3

Immunohistochemical quantifications of COX-2 and PCNA-positive cells and immunoblotting of HSP-70 in the colon of the animals submitted to the acute colitis model.

	COX-2 (𝜇m^2/mm^2)	PCNA (cells/mm^2)	HSP-70 (RU)
Non-colitic	4,058.65 ± 3356.31*	249.21 ± 18.49*	4.61
TNBS Control	24,207.99 ± 2614.22	399.34 ± 19.43	335.70
EC 10	9,257.06 ± 3110.30*	572.83 ± 15.69*	456.28
Sulfasalazine	14,635.04 ± 2039.01*	372.52 ± 24.85	541.07

Results are mean ± E.P.M. ANOVA-Dunnet. *P < 0.05 comparing to the TNBS control. n = 5–8. EC 10: Epicatechin, dose 10 mg/kg. RU: random units.