Epicatechin Used in the Treatment of Intestinal Inflammatory Disease: An Analysis by Experimental Models
Table 5
Biochemical quantifications of glutathione, myeloperoxidase, and alkaline phosphatase in the colon of animals submitted to the chronic colitis model.
Glutathione (GSH) (nmol/g)
GSH 1st week
GSH 2nd week
GSH 3rd week
Non-colitic
1,727.88 ± 95.34*
1,134.20 ± 79.27
1,726.73 ± 34.92*#
TNBS control
1,323.49 ± 43.15
1,353.74 ± 77.53
1,374.42 ± 77.55#
EC 10
1,662.56 ± 99.92*
1,236.37 ± 45.62
1,673.06 ± 82.37*#
EC 50
1,529.50 ± 87.26
1,150.68 ± 52.38
1,658.92 ± 110.49
Sulfasalazine
1,555.76 ± 141.52
1,269.79 ± 57.53
1,562.79 ± 110.64#
Not relapsed TNBS
—
—
1,914.64 ± 63.62*
Myeloperoxidase (MPO) (U/g)
MPO 1st week
MPO 2nd week
MPO 3rd week
Non-colitic
64.56 ± 19.05*
101.65 ± 6.63*
71.69 ± 5.64*#
TNBS control
377.52 ± 85.14
219.49 ± 25.09
634.42 ± 149.44#
EC 10
386.31 ± 76.80
247.64 ± 34.71
401.91 ± 70.28
EC 50
463.36 ± 98.97
211.67 ± 51.93
504.98 ± 144.73
Sulfasalazine
383.79 ± 81.39
179.12 ± 26.34
450.46 ± 73.96#
Not relapsed TNBS
—
—
225.23 ± 46.09*
Alkaline phosphatase (ALP) (mU/mg of protein)
ALP 1st week
ALP 2nd week
ALP 3rd week
Non-colitic
20.93 ± 2.21*
28.18 ± 1.56*
17.56 ± 1.39*
TNBS control
46.94 ± 2.62
40.02 ± 3.63
27.39 ± 3.76
EC 10
54.04 ± 6.67
34.96 ± 1.56
27.23 ± 2.10
EC 50
49.89 ± 7.95
48.16 ± 9.97
30.31 ± 1.20
Sulfasalazine
55.92 ± 7.85
39.40 ± 5.07
38.38 ± 4.96#
Not relapsed TNBS
—
—
24.25 ± 2.71
Results expressed as mean ± E.P.M. ANOVA-Dunnet comparing to the checks of each group. *P < 0.05 comparing to TNBS control, #P < 0.05 comparing to not relapsed TNBS control. n = 4–7. EC 10 and 50: Epicatechin, dose 10 and 50 mg/kg.
