Gastric Ulcers in Middle-Aged Rats: The Healing Effect of Essential Oil from Citrus aurantium L. (Rutaceae)

Table 3

Evaluation of toxicity in middle-aged rats of the essential oil (OEC) obtained from peels of Citrus aurantium after 14 consecutive days of treatment.

Treatment; (p.o.)		Control; (10 mL/kg)	Cimetidine; (100 mg/kg)	OEC; (250 mg/kg)
Weight; (arcosine)	Kidney	0.52 ± 0.04	0.51 ± 0.15	0.57 ± 0.05*
	Lungs	0.27 ± 0.19	0.33 ± 0.14	0.30 ± 0.16
	Liver	2.03 ± 0.14	2.07 ± 0.61*	2.32 ± 0.20**
	Heart	0.27 ± 0.05	0.28 ± 0.03	0.28 ± 0.06
	Spleen	0.14 ± 0.03	0.16 ± 0.03	0.15 ± 0.03
Biochemistry	Urea (mg/dL)	30.57 ± 4.29	34.13 ± 6.44	28.47 ± 3.40
	Creatinine (mg/dL)	0.76 ± 0.13	0.71 ± 0.08	0.75 ± 0.12
	AST (UI/L)	165.46 ± 30.59	180.73 ± 18.10	173.36 ± 33.23
	ALT (UI/I)	38.42 ± 4.32	35.80 ± 6.35	34.13 ± 5.87
	Glucose (UI/L)	79.57 ± 9.74	77.80 ± 9.49	76.87 ± 9.69

Results are mean ± SEM. ANOVA followed by Dunnett’s test. (𝑛=14-15), *P < 0.05, and**P < 0.01.