The Limbic-Prefrontal Network Modulated by Electroacupuncture at CV4 and CV12

Table 1

The regions showing post-EA effects.

Resting state (CV4)—True RS

Resting state (CV12)—True RS

CV4 versus CV12

Region (BA)

Lt (MNI Coordinate)

𝑇 value

Rt (MNI)

𝑇

Lt (MNI)

𝑇

Rt (MNI)

𝑇

Lt (MNI)

𝑇

Rt (MNI)

𝑇

MPF BA10/11

−12, 48, −8

4.8

8, 48, −14

5.9

−4, 44, −14

4.5

6, 48, −10

3.32

Orbital F BA11/12

16, 48, −12

5.67

18, 48, −12

3.09

Ventra ACC BA24/32

−6, 44, −4

4.3

4, 40, −10

5.32

−8, 40, 2

3.8

6, 34, −12

4.54

BA25

−8, 12, −12

2.8

2, 14, −14

3

−6, 18, −18

2.8

4, 10, −14

2.34

FP BA10

−16, 60, 10

2.1

Hypothalamus

2, 4, −12

2.76

Hp, HP

−34, −30, −8

3.5

18, −14, −20

2.01

−40, −28, −18

3.8

Amygdala

24, −8, −20

2.5

24, −8, −20

2.34

TP

38, 18, −42

3.24

SN

14, −12, −10

2.14

14, −12, −12

2.49

PCC BA

−10, −72, 50

1.88

LMF BA

−38, 24, 40

2.8

−24, 20, 42

2.6

Marginal gyrus BA40

54, −32, 38

2.67

44, −34, 22

2.6

PAG

−6, −34, −8

2.7

−4, −36, −8

2.46

Cerebellum

−10, −46, −58

3.7

−8, −76, −35

2.71

Note. (for CV4, 𝑛=20, for CV12, 𝑛=18, 𝑃<0.05/𝑇>1.3) True RS (resting state): The resting state session before sham EA.
MPF: medial prefrontal cortex, Orbital F: orbital frontal cortex, Ventra ACC: ventral anterior cingulate cortex, FP: frontal pole, HP: hippocampus, ParaHP: parahippocampus, TP: temporal pole, SN: substantial nigra, PCC: posterior cingulate cortex, LMF: lateral middle frontal cortex, and PAG: periaqueductal gray matter.
The brain regions showing enhanced post-EA local connectivity were similar for two acupoints: medial prefrontal cortex BA10/11, anteroinferior portion of the anterior cingulate cortex BA24/32, BA25, followed by hippocampus, parahippocampus. Differences were seen in Amygdala and Marginal gyrus, BA40 (CV4 > CV12).