Review Article

A Review of Acupoint Specificity Research in China: Status Quo and Prospects

Table 1

RCT studies of acupoint specificity in China.

TrialResearch objectSample sizeGroupsPrimary outcomeResult

Li et al. [26]Patients with acute migraine attacks180Verum acupuncture group: Waiguan (TE5), Yanglingquan (GB 34), Qiuxu (GB 40), Jiaosun (TE 20), Fengchi (GB 20)
Sham acupuncture group one: (1) At the medial arm on the anterior border of the insertion of the deltoid muscle at the junction of the deltoid and biceps muscles; (2) Halfway between the tip of the elbow and the axillae; (3) Ulnar side, halfway between the epicodylus medialis of the humerus and the ulnar side of the wrist; (4) The edge of the tibia 1-2 cm lateral to the Zusanli (ST36) horizontally; (5) The inside of the mid-thigh region 2 cm lateral to half the distance from the anterior superior iliac spine to the lateral superior corner of the patella on the rectus femoris;
Sham acupuncture group two: (1) located halfway between the triple energizer and small intestine meridians lateral to Waiguan (TE 5) horizontally; (2) halfway between the line from Qiuxu (GB 40) to Jiexi (ST 41); (3) halfway between the gallbladder and bladder meridians lateral to Yanglingquan (GB 34) horizontally; (4) halfway between the line from Jiaosun (TE 20) to Shuaigu (GB 8); (5) halfway between the line from Fengchi (GB 20) to Anmian (extra point) bilaterally
Pain (VAS scores)+

Li et al. [27]Migraine patients480Group one: Waiguan (TE5), Yanglingquan (GB34), Qiuxu (GB40), Fengchi (GB20)
Group two: Luxi (TE19), Sanyangluo (TE8), Xiyangguan (GB33), Diwuhui (GB42)
Group three: Touwei (ST8), Pianli (LI6), Zusanli (ST36), Chongyang (ST42)
Group four: (1) At the medial arm on the anterior border of the insertion of the deltoid muscle at the junction of the deltoid and biceps muscles; (2) Halfway between the tip of the elbow and the axillae; (3) Ulnar side, halfway between the epicodylus medialis of the humerus and the ulnar side of the wrist; (4) The edge of the tibia 1-2 cm lateral to the Zusanli (ST36) horizontally
Number of days with a migraine

Ma et al. [29]FD patients712Group one: Chongyang (ST42), Fenglong (ST40), Zusanli (ST36), Liangqiu (ST34)
Group two: Tiaokou (ST38), Dubi (ST35), Yinshi (ST33), Futu (ST32)
Group three: Weishu (BL21), Zhongwan (CV12)
Group four: Qiuxu (GB40), Guangming (GB37), Yanglingquan (GB34), Waiqiu (GB36)
Group five: the same with group four in migraine study (sample size: 480)
Group six: itopride (take orally)
SID scores+

Yu et al. [30]PD patients66Treatment group: Sanyinjiao (SP6)
Control group: Xuanzhong (GB39)
PI, RI, A/B+

Liu et al. [31]PD patients200Acupoint group: Sanyinjiao (SP6)
Unrelated acupoint group: Xuanzhong (GB39)
Non-acupoint group: lateral side of lower leg, 3 inches above the tip of external malleolus, 1.5 inches behind anterior crest of the tibia
No acupuncture group
Pain (VAS scores)

Liu, MaPD patients501Acupoint group: Sanyinjiao (SP6)
Unrelated acupoint group: Xuanzhong (GB39)
Non-acupoint group: lateral side of lower leg, 3 inches above the tip of external malleolus, 1.5 inches behind anterior crest of the tibia
Pain (VAS scores)+

Shen et al. [34]Patients with ischemic stroke290Acupoint group: basic acupoints-Neiguan (PC6), Shuigou (DU26), Sanyinjiao (SP6); additional acupoints-Jiquan (HT1), Weizhong (BL40), Chize (LU5)
Non-acupoint group: located 3 mm apart from acupoints mentioned above
Global symptoms (BI, relapse rate,+

Notes: “+” refers to the trial detected different outcomes between acupoint and non-acupoint/inactive acupoint; “−” denotes that the trial did not detect different outcomes between acupoint and non-acupoint/inactive acupoint.
PI: pulsatility index; RI: resistance index; BI: barthel indix.