Refined Qingkailing Protects MCAO Mice from Endoplasmic Reticulum Stress-Induced Apoptosis with a Broad Time Window

Figure 2

Effect of different doses of RQKL on infarction volume and neurological function of MCAO mouse. Five brain coronal sections, 2 mm thick, were selected for tetrazolium chloride staining. The infarct volume was quantified as a percentage of total volume, with large infarcts representing more severe injury. The percent of infarct volume was significantly less in RQKL injection groups compared with model group (a). RQKL injection at different doses significantly improve focal and general neurological function (b, c). The scores of focal neurological function and general neurological function were 0 in normal mice. High scores represent severe injury. ^ΔΔ𝑃<0.01, versus model group, ^#𝑃<0.05, ^##𝑃<0.01, versus model group. Data are expressed as mean ± SEM, 𝑛=10.

(a)

(b)

(c)