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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 568106, 19 pages
http://dx.doi.org/10.1155/2012/568106
Review Article

Efficacy and Side Effects of Chinese Herbal Medicine for Menopausal Symptoms: A Critical Review

1Gynecology Department, Yueyang Integrated Traditional Chinese Medicine and Western Medicine Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
2HanseMerkur Traditional Chinese Medicine Centre, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany
3Department of Internal Medicine, University Teaching Hospital Itzehoe, 25524 Itzehoe, Germany
4Clinical Evaluation Centre, Longhua Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
5Technology Information Centre, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
6Gynecology Department, Shuguang Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China
7Laboratory for Research and Diagnostics, Departments of Maxillofacial Surgery and Neurology, University Medical Center Hamburg-Eppendorf, Martinistraβe 52, 20246 Hamburg, Germany

Received 27 July 2012; Accepted 3 October 2012

Academic Editor: V. C. N. Wong

Copyright © 2012 Lian-Wei Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. North American Menopause Society, “Estrogen and progestogen use in peri- and postmenopausal women: March 2007 position statement of The North American Menopause Society,” Menopause, vol. 14, no. 2, pp. 168–182, 2007.
  2. F. Kronenberg, “Hot flashes: phenomenology, quality of life, and search for treatment options,” Experimental Gerontology, vol. 29, no. 3-4, pp. 319–336, 1994. View at Publisher · View at Google Scholar · View at Scopus
  3. H. D. Nelson, “Menopause,” The Lancet, vol. 371, no. 9614, pp. 760–770, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Xu, H. Zhao, and Q. S. Ge, “Epidemiology of perimenopause,” Journal of Reproductive Medicine, vol. 2, no. 1, pp. 23–27, 1993 (Chinese).
  5. F. Kronenberg, “Hot flashes: epidemiology and physiology,” Annals of the New York Academy of Sciences, vol. 592, pp. 52–86, 1990.
  6. V. Stearns, L. Ullmer, J. F. Lo'pez, Y. Smith, C. Isaacs, and D. F. Hayes, “Hot flushes,” The Lancet, vol. 360, no. 9348, pp. 1851–1861, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Rödström, C. Bengtsson, L. Lissner, I. Milsom, V. Sundh, and C. Björkelund, “A longitudinal study of the treatment of hot flushes: the population study of women in Gothenburg during a quarter of a century,” Menopause, vol. 9, no. 3, pp. 156–161, 2002. View at Scopus
  8. N. E. Avis, A. Colvin, J. T. Bromberger et al., “Change in health-related quality of life over the menopausal transition in a multiethnic cohort of middle-aged women: Study of Women's Health Across the Nation,” Menopause, vol. 16, no. 5, pp. 860–869, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. G. D. Mishra, W. J. Brown, and A. J. Dobson, “Physical and mental health: changes during menopause transition,” Quality of Life Research, vol. 12, no. 4, pp. 405–412, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. E. B. Gold, J. Bromberger, S. Crawford et al., “Factors associated with age at natural menopause in a multiethnic sample of midlife women,” American Journal of Epidemiology, vol. 153, no. 9, pp. 865–874, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. R. F. Casper, “Clinical manifestations and diagnosis of menopause,” 2009, http://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-menopause.
  12. National Institutes of Health, “National Institutes of Health State-of-the-Science Conference Statement: management of Menopause-related symptoms,” Annals of Internal Medicine, vol. 142, no. 12, part 1, pp. 1003–1013, 2005.
  13. S. Elavsky and E. McAuley, “Personality, menopausal symptoms, and physical activity outcomes in middle-aged women,” Personality and Individual Differences, vol. 46, no. 2, pp. 123–128, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. H. S. Kupperman, B. B. Wetchler, and M. H. Blatt, “Contemporary therapy of the menopausal syndrome,” The Journal of the American Medical Association, vol. 171, pp. 1627–1637, 1959. View at Scopus
  15. J. G. Greene, “Constructing a standard climacteric scale,” Maturitas, vol. 29, no. 1, pp. 25–31, 1998. View at Publisher · View at Google Scholar · View at Scopus
  16. L. A. J. Heinemann, P. Potthoff, and H. P. G. Schneider, “International versions of the Menopause Rating Scale (MRS),” Health and Quality of Life Outcomes, vol. 1, article 28, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. W. H. Utian, D. F. Archer, G. A. Bachmann et al., “Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause Society,” Menopause, vol. 15, no. 4, part 1, pp. 584–602, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. H. D. Nelson, “Commonly used types of postmenopausal estrogen for treatment of hot flashes: scientific review,” Journal of the American Medical Association, vol. 291, no. 13, pp. 1610–1620, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. V. Beral, G. Reeves, D. Bull, and J. Green, “Breast cancer risk in relation to the interval between menopause and starting hormone therapy,” Journal of the National Cancer Institute, vol. 103, no. 4, pp. 296–305, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. J. V. Lacey Jr., L. A. Brinton, M. F. Leitzmann et al., “Menopausal hormone therapy and ovarian cancer risk in the National Institutes of Health-AARP Diet and Health Study Cohort,” Journal of the National Cancer Institute, vol. 98, no. 19, pp. 1397–1405, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Furness, H. Roberts, J. Marjoribanks, A. Lethaby, M. Hickey, and C. Farquhar, “Hormone therapy in postmenopausal women and risk of endometrial hyperplasia,” Cochrane Database of Systematic Reviews, no. 2, p. CD000402, 2009. View at Scopus
  22. V. Beral, D. Bull, and G. Reeves, “Million Women Study Collaborators. Endometrial cancer and hormone-replacement therapy in the Million Women Study,” The Lancet, vol. 365, no. 9470, pp. 1543–1551, 2005.
  23. C. Farquhar, J. Marjoribanks, A. Lethaby, J. A. Suckling, and Q. Lamberts, “Long term hormone therapy for perimenopausal and postmenopausal women,” Cochrane Database of Systematic Reviews, no. 2, p. CD004143, 2009. View at Scopus
  24. J. E. Rossouw, G. L. Anderson, R. L. Prentice et al., “Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial,” Journal of the American Medical Association, vol. 288, no. 3, pp. 321–333, 2002. View at Scopus
  25. G. L. Anderson, M. Limacher, A. R. Assaf, et al., “Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative Randomized Controlled Trial,” Journal of the American Medical Association, vol. 291, no. 14, pp. 1701–1712, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. “Herbal medicines for menopausal symptoms,” Drug and Therapeutics Bulletin, vol. 47, no. 1, pp. 2–6, 2009.
  27. H. J. Kang, R. Ansbacher, and M. M. Hammoud, “Use of alternative and complementary medicine in menopause,” International Journal of Gynecology and Obstetrics, vol. 79, no. 3, pp. 195–207, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. B. Singh, X. D. Liu, C. Der-Martirosian et al., “A national probability survey of American Medical Association gynecologists and primary care physicians concerning menopause,” American Journal of Obstetrics and Gynecology, vol. 193, no. 3, part 1, pp. 693–700, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. L. C. Chen, B. R. Wang, I. C. Chen, and C. H. Shao, “Use of Chinese herbal medicine among menopausal women in Taiwan,” International Journal of Gynecology & Obstetrics, vol. 109, no. 1, pp. 63–66, 2010.
  30. V. Scheid, “Traditional Chinese medicine-What are we investigating?. The case of menopause,” Complementary Therapies in Medicine, vol. 15, no. 1, pp. 54–68, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. F. Liu, C. Z. Xiao, T. F. Wang, L. H. Zhang, and K. J. Ding, “Analyzing characteristics of Chinese herbal medical, symptoms, pattern distribution of traditional Chinese medicine for menopausal syndrome in modern literatures,” Journal of Beijing University of Traditional Chinese Medicine, vol. 31, no. 2, pp. 125–130, 2008 (Chinese).
  32. D. T. X. Hong, S. Y. Liu, and G. X. He, “Review on Chinese medical treatment for menopausal syndrome,” Chinese Journal of Information on Traditional Chinese Medicine, vol. 17, pp. 123–124, 2010.
  33. Y. Feng and P. X. Cao, “Review on Chinese medical treatment for menopausal syndrome,” Journal of Liaoning University of Traditional Chinese Medicine, vol. 4, no. 12, pp. 125–126, 2010 (Chinese).
  34. G. A. Plotnikoff, K. Watanabe, C. Torkelson, J. La Valleur, and D. M. Radosevich, “The TU-025 keishibukuryogan clinical trial for hot flash management in postmenopausal women: results and lessons for future research,” Menopause, vol. 18, no. 8, pp. 886–892, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. B. Pan, Y. Kato, K. Sengoku, N. Takuma, N. Niizeki, and M. Ishikawa, “Treatment of climacteric symptoms with herbal formulas of traditional Chinese medicine,” Gynecologic and Obstetric Investigation, vol. 57, no. 3, pp. 144–148, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. V. Scheid, T. Ward, W. S. Cha, K. Watanabe, and X. Liao, “The treatment of menopausal symptoms by traditional East Asian medicines: review and perspectives,” Maturitas, vol. 66, no. 2, pp. 111–130, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. A. L. Huntley and E. Ernst, “A systematic review of herbal medicinal products for the treatment of menopausal symptoms,” Menopause, vol. 10, no. 5, pp. 465–476, 2003. View at Scopus
  38. Y. N. Clement, I. Onakpoya, S. K. Hung, and E. Ernst, “Effects of herbal and dietary supplements on cognition in menopause: a systematic review,” Maturitas, vol. 68, no. 3, pp. 256–263, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. R. Haimov-Kochman and D. Hochner-Celnikier, “Hot flashes revisited: pharmacological and herbal options for hot flashes management. What does the evidence tell us?” Acta Obstetricia et Gynecologica Scandinavica, vol. 84, no. 10, pp. 972–979, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. L. W. Xu, S. J. Zhang, and Z. J. Sun, “Characteristics of etiology and pathogenesis of traditional Chinese medicine for menopausal syndrome,” Journal of Traditional Chinese Medicine, vol. 49, no. 11, pp. 1031–1033, 2008.
  41. Y. Z. Zhang, Ed., Obstetrics and Gynecology of Chinese Medicine, Chinese Traditional Chinese Medicine Press, Beijing, China, 1st edition, 2002.
  42. S. P. Luo, Obstetrics and Gynecology of Chinese Medicine, Higher Education Press, Beijing, China, 1st edition, 2008.
  43. Q. Wang and R. S. Xu, “Chinese medical understanding on menopausal syndrome,” Journal of Traditional Chinese Medicine, vol. 47, no. 2, pp. 151–152, 2006 (Chinese).
  44. Q. Yu and X. Chen, “A review on Chinese medical treatment for menopausal syndrome,” Journal of Liaoning University of Traditional Chinese Medicine, vol. 11, no. 2, pp. 47–48, 2009 (Chinese).
  45. C. F. Du, T. F. Wang, Y. Xing et al., “Logistic regression analysis on common syndrome factor of postmenopausal menopause syndrome (Logistic),” Journal of Beijing University of Traditional Chinese Medicine, vol. 32, no. 4, pp. 238–243, 2009 (Chinese).
  46. L. Li, J. Ren, C. F. Du, Y. Xing, and T. F. Wang, “Literature analyses on distribution characteristics of TCM syndromes and syndrome elements of menopausal syndrome,” Journal of China Chinese Medicine, vol. 23, no. 3, pp. 194–197, 2008 (Chinese).
  47. C. F. Du, T. F. Wang, X. Y. Wu, Y. Zhao, and Q. G. Wang, “Common syndrome factors of menopausal syndrome based on questionnaire investigation among experts,” Journal of Chinese Integrative Medicine, vol. 8, no. 8, pp. 757–761, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. X. Zhu, J. Clarke, ProctorM, and Y. L. Liew, “Chinese herbal medicine for menopausal symptoms (protocol),” Cochrane Database of Systematic Reviews, no. 3, article CD009023, 2011.
  49. K. Terasawa, “Evidence-based reconstruction of Kampo medicine: Part I- Is Kampo CAM?” Evidence-Based Complementary and Alternative Medicine, vol. 1, no. 1, pp. 11–16, 2004.
  50. S. Watanabe, J. Imanishi, M. Satoh, and K. Ozasa, “Unique place of Kampo (Japanese traditional medicine) in complementary and alternative medicine: a survey of doctors belonging to the regional medical association in Japan,” Tohoku Journal of Experimental Medicine, vol. 194, no. 1, pp. 55–63, 2001. View at Publisher · View at Google Scholar · View at Scopus
  51. A. T. Borchers, R. M. Hackman, C. L. Keen, J. S. Stern, and M. E. Gershwin, “Complementary medicine: a review of immunomodulatory effects of Chinese herbal medicines,” American Journal of Clinical Nutrition, vol. 66, no. 6, pp. 1303–1312, 1997. View at Scopus
  52. A. R. Jadad, R. A. Moore, D. Carroll et al., “Assessing the quality of reports of randomized clinical trials: is blinding necessary?” Controlled Clinical Trials, vol. 17, no. 1, pp. 1–12, 1996. View at Publisher · View at Google Scholar · View at Scopus
  53. J. D. Hirata, L. M. Swiersz, B. Zell, R. Small, and B. Ettinger, “Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial,” Fertility and Sterility, vol. 68, no. 6, pp. 981–986, 1997. View at Publisher · View at Google Scholar · View at Scopus
  54. J. Woo, E. Lau, S. C. Ho et al., “Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause,” Menopause, vol. 10, no. 4, pp. 352–361, 2003. View at Scopus
  55. C. J. Haines, P. M. Lam, T. K. H. Chung, K. F. Cheng, and P. C. Leung, “A randomized, double-blind, placebo-controlled study of the effect of a Chinese herbal medicine preparation (Dang Gui Buxue Tang) on menopausal symptoms in Hong Kong Chinese women,” Climacteric, vol. 11, no. 3, pp. 244–251, 2008. View at Publisher · View at Google Scholar · View at Scopus
  56. S. R. Davis, E. M. Briganti, R. Q. Chen, F. S. Dalais, M. Bailey, and H. G. Burger, “The effects of Chinese medicinal herbs on postmenopausal vasomotor symptoms of Australian women: a randomised controlled trial,” Medical Journal of Australia, vol. 174, no. 2, pp. 68–71, 2001. View at Scopus
  57. T. Yasui, M. Yamada, H. Uemura et al., “Changes in circulating cytokine levels in midlife women with psychological symptoms with selective serotonin reuptake inhibitor and Japanese traditional medicine,” Maturitas, vol. 62, no. 2, pp. 146–152, 2009. View at Publisher · View at Google Scholar · View at Scopus
  58. I. K. Wiklund, L. Å. Mattsson, R. Lindgren, and C. Limoni, “Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial,” International Journal of Clinical Pharmacology Research, vol. 19, no. 3, pp. 89–99, 1999. View at Scopus
  59. D. Grady, G. F. Sawaya, K. C. Johnson et al., “MF101, a selective estrogen receptor β modulator for the treatment of menopausal hot flushes: a phase II clinical trial,” Menopause, vol. 16, no. 3, pp. 458–465, 2009. View at Publisher · View at Google Scholar · View at Scopus
  60. L. C. Chen, Y. T. Tsao, K. Y. Yen, Y. F. Chen, M. H. Chou, and M. F. Lin, “A pilot study comparing the clinical effects of Jia-Wey Shiau-Yau San, a traditional Chinese herbal prescription, and a continuous combined hormone replacement therapy in postmenopausal women with climacteric symptoms,” Maturitas, vol. 44, no. 1, pp. 55–62, 2003. View at Publisher · View at Google Scholar · View at Scopus
  61. J. Zheng, J. Li, S. Ni, and L. Zhang, “Clinical observation of combinative Chinese medicine in treating perimenopausal syndrome,” Shanghai Journal of Traditional Chinese Medicine, vol. 43, no. 10, pp. 30–32, 2009 (Chinese).
  62. L. J. Wei and N. X. Luo, “The clinical study of qian jin ba on treating climateric syndrome,” Beijing Journal of Traditional Chinese Medicine, vol. 26, no. 9, pp. 561–563, 2007.
  63. F. Qu, X. Cai, Y. Gu et al., “Chinese medicinal herbs in relieving perimenopausal depression: a randomized, controlled trial,” The Journal of Alternative and Complementary Medicine, vol. 15, no. 1, pp. 93–100, 2009. View at Publisher · View at Google Scholar · View at Scopus
  64. A. Chang, B. Y. Kwak, K. Yi, and J. S. Kim, “The effect of herbal extract (EstroG-100) on pre-, peri- and post-menopausal women: a Randomized Double-blind, Placebo-controlled Study,” Phytotherapy Research, vol. 26, no. 4, pp. 510–5516, 2012. View at Publisher · View at Google Scholar
  65. S. Y. Kim, S. K. Seo, Y. M. Choi et al., “Effects of red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: a double-blind randomized controlled trial,” Menopause, vol. 19, no. 4, pp. 461–466, 2012.
  66. C. C. Hsu, H. C. Kuo, S. Y. Chang, T. C. Wu, and K. E. Huang, “The assessment of efficacy of Diascorea alata for menopausal symptom treatment in Taiwanese women,” Climacteric, vol. 14, no. 1, pp. 132–139, 2011. View at Publisher · View at Google Scholar · View at Scopus
  67. S. H. Kwee, H. H. Tan, A. Marsman, and C. Wauters, “The effect of Chinese herbal medicines (CHM) on menopausal symptoms compared to hormone replacement therapy (HRT) and placebo,” Maturitas, vol. 58, no. 1, pp. 83–90, 2007. View at Publisher · View at Google Scholar · View at Scopus
  68. R. Chen, S. Q. Lin, X. Yang et al., “A randomized, mutlti-center, double blind and parallel controlled clinical trial for Kuntai capsules in the treatment of climacteric syndromes,” Chinese New Drugs Journal, vol. 14, no. 12, pp. 1472–1476, 2005 (Chinese).
  69. H. Lou, D. Huang, S. Fang, X. Zhao, Q. Huang, and M. Wang, “Clinic research on Xianling Gubao capsules for treatment of manopause syndrome,” China Journal of Chinese Materia Medica, vol. 34, no. 22, pp. 2950–2952, 2009. View at Scopus
  70. X. Y. Wang, H. Y. Yang, C. L. Zhang, Z. H. Wen, T. Y. Si, H. Z. Jiang, et al., “Randomized controlled trial on combination of tonifying-kidney Chinese herbs and Chinese medical psychological treatment for menopausal syndrome,” Journal of Southern Medical University, vol. 26, no. 6, pp. 797–798, 2006 (Chinese).
  71. C. Wu, Y. B. Zhang, B. X. Yin, and L. H. Chen, “Clinic research on new indication of Jing Qian Ping granule for menopausal syndrome,” Chinese Traditional Patent Medicine, vol. 31, no. 11, pp. 7–8, 2009 (Chinese).
  72. X. H. Li, W. M. Deng, J. Y. Zhang, L. Zhou, and W. Y. Huang, “Effect of bu shen zhuang gu granule on the gonadal hormone and blood lipids metabolism in climacteric women,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 29, no. 7, pp. 599–602, 2009 (Chinese).
  73. J. J. Li, A. Z. Pan, and W. M. Yi, “The effect of gengnianningshentang on treating 72 patients with female climacteric syndrome of fever due to yin-deficiency,” Journal of Chinese Medicinal Materials, vol. 31, no. 4, pp. 628–630, 2008. View at Scopus
  74. H. H. Liu, S. Lu, and Y. P. Shi, “Clinical observation on Ziyin Jianghuo Fang for the treatment of 60 patients with menopausal syndrom caused by deficiency of yin and exess of fire,” Chinese Journal of Experimental Traditional Medical Formulae, no. 19, pp. 268–270, 2011 (Chinese).
  75. Chinese Ministry of Health, New Chinese Medicine Clinical Research Guidelines, China Medical Science and Technology Press, Beijing, China, 1997.