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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 579321, 9 pages
http://dx.doi.org/10.1155/2012/579321
Review Article

Acupuncture as Treatment of Hot Flashes and the Possible Role of Calcitonin Gene-Related Peptide

1Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, 581 85 Linköping, Sweden
2Department of Obstetrics and Gynecology in Linköping, County Council of Östergötland, 581 85 Linköping, Sweden

Received 1 May 2011; Accepted 29 August 2011

Academic Editor: Fengxia Liang

Copyright © 2012 Anna-Clara E. Spetz Holm et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Hammar, G. Berg, L. Fahraeus, and U. Larsson-Cohn, “Climacteric symptoms in an unselected sample of Swedish women,” Maturitas, vol. 6, no. 4, pp. 345–350, 1984. View at Scopus
  2. S. M. McKinlay, D. J. Brambilla, and J. G. Posner, “The normal menopause transition,” Maturitas, vol. 14, no. 2, pp. 103–115, 1992. View at Scopus
  3. C. Huggins, R. C. Stevens, and C. V. Hodges, “Studies on prostatic cancer. II. The effect of castration of advanced carcinoma of the prostate gland,” Archives of Surgery, vol. 43, pp. 209–223, 1941.
  4. P. Karling, M. Hammar, and E. Varenhorst, “Prevalence and duration of hot flushes after surgical or medical castration in men with prostatic carcinoma,” Journal of Urology, vol. 152, no. 4, pp. 1170–1173, 1994.
  5. EP McCullagh and JF Renshaw, “The effect of castration in the adult male,” JAMA, vol. 103, no. 15, pp. 1140–1143, 1934.
  6. J. M. Feldman, R. W. Postlethwaite, and J. F. Glenn, “Hot flashes and sweats in men with testicular insufficiency,” Archives of Internal Medicine, vol. 136, no. 5, pp. 606–608, 1976. View at Publisher · View at Google Scholar · View at Scopus
  7. A. C. E. Spetz, M. G. Fredriksson, and M. L. Hammar, “Hot flushes in a male population aged 55, 65, and 75 years, living in the community of Linköping, Sweden,” Menopause, vol. 10, no. 1, pp. 81–87, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. R. R. Freedman, “Laboratory and ambulatory monitoring of menopausal hot flashes,” Psychophysiology, vol. 26, no. 5, pp. 573–578, 1989. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Frodin, G. Alund, and E. Varenhorst, “Measurement of skin blood-flow and water evaporation as a means of objectively assessing hot flushes after orchidectomy in patients with prostatic cancer,” Prostate, vol. 7, no. 2, pp. 203–208, 1985. View at Scopus
  10. J. Ginsburg and B. O'Reilly, “Climacteric flushing in a man,” British Medical Journal, vol. 287, no. 6387, p. 262, 1983. View at Scopus
  11. A.-C. Spetz, B. Pettersson, E. Varenhorst, E. Theodorsson, L.-H. Thorell, and M. Hammar, “Momentary increase in plasma calcitonin gene-related peptide is involved in hot flashes in men treated with castration for carcinoma of the prostate,” Journal of Urology, vol. 166, no. 5, pp. 1720–1723, 2001.
  12. W. Shen and V. Stearns, “Treatment strategies for hot flushes,” Expert Opinion on Pharmacotherapy, vol. 10, no. 7, pp. 1133–1144, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. R. R. Freedman and M. Subramanian, “Effects of symptomatic status and the menstrual cycle on hot flash-related thermoregulatory parameters,” Menopause, vol. 12, no. 2, pp. 156–159, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. V. Stearns, “Clinical update: new treatments for hot flushes,” Lancet, vol. 369, no. 9579, pp. 2062–2064, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. P. Lomax and E. Schonbaum, “Postmenopausal hot flushes and their management,” Pharmacology and Therapeutics, vol. 57, no. 2-3, pp. 347–358, 1993. View at Scopus
  16. R. W. Rebar and I. B. Spitzer, “The physiology and measurement of hot flushes,” American Journal of Obstetrics and Gynecology, vol. 156, no. 5, pp. 1284–1288, 1987. View at Scopus
  17. H. H. G. Berendsen, “The role of serotonin in hot flushes,” Maturitas, vol. 36, no. 3, pp. 155–164, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. D. W. Sturdee, “The menopausal hot flush—anything new?” Maturitas, vol. 60, no. 1, pp. 42–49, 2008. View at Publisher · View at Google Scholar · View at PubMed
  19. R. F. Casper and S. S. C. Yen, “Neuroendocrinology of menopausal flushes: an hypothesis of flush mechanism,” Clinical Endocrinology, vol. 22, no. 3, pp. 293–312, 1985. View at Scopus
  20. R. R. Freedman, D. Norton, S. Woodward, and G. Cornelissen, “Core body temperature and circadian rhythm of hot flashes in menopausal women,” Journal of Clinical Endocrinology and Metabolism, vol. 80, no. 8, pp. 2354–2358, 1995. View at Scopus
  21. R. R. Freedman and W. Krell, “Reduced thermoregulatory null zone in postmenopausal women with hot flashes,” American Journal of Obstetrics and Gynecology, vol. 181, no. 1, pp. 66–70, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Wyon, R. Lindgren, T. Lundeberg, and M. Hammar, “Effects of acupuncture on climacteric vasomotor symptoms, quality of life and urinary excretion of neuropeptides among postmenopausal women,” Menopause, vol. 2, pp. 3–12, 1995.
  23. E. Collin, D. Frechilla, M. Pohl et al., “Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivo,” Brain Research, vol. 609, no. 1-2, pp. 211–222, 1993. View at Scopus
  24. R. Uddman, L. Edvinsson, and E. Ekblad, “Calcitonin gene-related peptide (CGRP): perivascular distribution and vasodilatory effects,” Regulatory Peptides, vol. 15, no. 1, pp. 1–23, 1986.
  25. J. Jernbeck, M. Edner, C. J. Dalsgaard, and B. Pernow, “The effect of calcitonin gene-related peptide (CGRP) on human forearm blood flow,” Clinical Physiology, vol. 10, no. 4, pp. 335–343, 1990. View at Scopus
  26. J. T. Chen, Y. Hirai, Y. Seimiya, and K. Hasumi, “Menopausal flushes and calcitonin-gene-related peptide,” Lancet, vol. 342, no. 8862, p. 49, 1993. View at Scopus
  27. A. Valentini, F. Petraglia, D. De Vita et al., “Changes of plasma calcitonin gene-related peptide levels in postmenopausal women,” American Journal of Obstetrics and Gynecology, vol. 175, no. 3, pp. 638–642, 1996. View at Scopus
  28. Y. A. M. Wyon, A. C. E. Spetz, G. E. Theodorsson, and M. L. Hammar, “Concentrations of calcitonin gene-related peptide and neuropeptide Y in plasma increase during flushes in postmenopausal women,” Menopause, vol. 7, no. 1, pp. 25–30, 2000. View at Scopus
  29. J. T. Chen and M. Shiraki, “Menopausal hot flash and calciotonin gene-related peptide; effect of Keishi-bukuryo-gan, a kampo medicine, related to plasma calciotonin gene-related peptide level,” Maturitas, vol. 45, no. 3, pp. 199–204, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Wyon, J. Frisk, T. Lundeberg, E. Theodorsson, and M. Hammar, “Postmenopausal women with vasomotor symptoms have increased urinary excretion of calcitonin gene-related peptide,” Maturitas, vol. 30, no. 3, pp. 289–294, 1998. View at Publisher · View at Google Scholar · View at Scopus
  31. A. H. Maclennan, J. L. Broadbent, S. Lester, and V. Moore, “Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes,” Cochrane Database of Systematic Reviews, no. 4, Article ID CD002978, 2004.
  32. D. M. Herrington, E. Vittinghoff, F. Lin et al., “Statin therapy, cardiovascular events, and total mortality in the Heart and Estrogen/progestin Replacement Study (HERS),” Circulation, vol. 105, no. 25, pp. 2962–2967, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. V. Beral, “Breast cancer and hormone-replacement therapy in the Million Women Study,” Lancet, vol. 362, no. 9382, pp. 419–427, 2003. View at Publisher · View at Google Scholar
  34. F. Borrelli and E. Ernst, “Alternative and complementary therapies for the menopause,” Maturitas, vol. 66, no. 4, pp. 333–343, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. G. Bertelli, M. Venturini, L. Del Mastro et al., “Intramuscular depot medroxyprogesterone versus oral megestrol for the control of postmenopausal hot flashes in breast cancer patients: a randomised study,” Annals of Oncology, vol. 13, no. 6, pp. 883–888, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. J. C. Prior, J. D. Nielsen, C. L. Hitchcock, L. A. Williams, Y. M. Vigna, and C. B. Dean, “Medroxyprogesterone and conjugated oestrogen are equivalent for hot flushes: a 1-year randomized double-blind trial following premenopausal ovariectomy,” Clinical Science, vol. 112, no. 9-10, pp. 517–525, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. M. L. Hammar, P. Van De Weijer, H. R. Franke, B. Pornel, E. M. J. Von Mauw, and E. A. Nijland, “Tibolone and low-dose continuous combined hormone treatment: vaginal bleeding pattern, efficacy and tolerability,” BJOG, vol. 114, no. 12, pp. 1522–1529, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  38. S. G. Swanson, S. Drosman, F. A. Helmond, and V. M. Stathopoulos, “Tibolone for the treatment of moderate to severe vasomotor symptoms and genital atrophy in postmenopausal women: a multicenter, randomized, double-blind, placebo-controlled study,” Menopause, vol. 13, no. 6, pp. 917–925, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  39. P. Kenemans, N. J. Bundred, J.-M. Foidart et al., “Safety and efficacy of tibolone in breast-cancer patients with vasomotor symptoms: a double-blind, randomised, non-inferiority trial,” The Lancet Oncology, vol. 10, no. 2, pp. 135–146, 2009. View at Publisher · View at Google Scholar
  40. V. C. K. Wong, C. E. D. Lim, X. Luo, and W. S. F. Wong, “Current alternative and complementary therapies used in menopause,” Gynecological Endocrinology, vol. 25, no. 3, pp. 166–174, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  41. P. Albertazzi, “Non-estrogenic approaches for the treatment of climacteric symptoms,” Climacteric, vol. 10, no. 2, pp. 115–120, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  42. C. M. Kelly, D. N. Juurlink, T. Gomes et al., “Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study.,” BMJ, vol. 340, article c693, 2010. View at Publisher · View at Google Scholar
  43. P. Albertazzi, “Noradrenergic and serotonergic modulation to treat vasomotor symptoms,” Journal of the British Menopause Society, vol. 12, no. 1, pp. 7–11, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  44. G. A. Greendale and E. B. Gold, “Lifestyle factors: are they related to vasomotor symptoms and do they modify the effectiveness or side effects of hormone therapy?” American Journal of Medicine, vol. 118, no. 12, pp. 148–154, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  45. A. Daley, C. MacArthur, N. Mutrie, and H. Stokes-Lampard, “Exercise for vasomotor menopausal symptoms,” Cochrane Database of Systematic Reviews, no. 4, Article ID CD006108, 2007.
  46. M. Hammar, G. Berg, and R. Lindgren, “Does physical exercise influence the frequency of postmenopausal hot flushes?” Acta Obstetricia et Gynecologica Scandinavica, vol. 69, no. 5, pp. 409–412, 1990. View at Scopus
  47. T. Ivarsson, A. C. Spetz, and M. Hammar, “Physical exercise and vasomotor symptoms in postmenopausal women,” Maturitas, vol. 29, no. 2, pp. 139–146, 1998. View at Publisher · View at Google Scholar · View at Scopus
  48. M. Hammar, J. Frisk, O. Grimås, M. Höök, A. C. Spetz, and Y. Wyon, “Acupuncture treatment of vasomotor symptoms in men with prostatic carcinoma: a pilot study,” Journal of Urology, vol. 161, no. 3, pp. 853–856, 1999. View at Publisher · View at Google Scholar · View at Scopus
  49. E. Nedstrand, K. Wijma, Y. Wyon, and M. Hammar, “Vasomotor symptoms decrease in women with breast cancer randomized to treatment with applied relaxation or electro-acupuncture: a preliminary study,” Climacteric, vol. 8, no. 3, pp. 243–250, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  50. S. M. Cohen, M. E. Rosseau, and B. L. Carey, “Can acupuncture relieve symptoms of the menopause?” Holistic Nursing Practice, vol. 17, pp. 295–299, 2003.
  51. Y. Nir, M. I. Huang, R. Schnyer, B. Chen, and R. Manber, “Acupuncture for postmenopausal hot flashes,” Maturitas, vol. 56, no. 4, pp. 383–395, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  52. J. Frisk, S. Carlhäll, A. C. Källström, L. Lindh-Åstrand, A. Malmström, and M. Hammar, “Long-term follow-up of acupuncture and hormone therapy on hot flushes in women with breast cancer: a prospective, randomized, controlled multicenter trial,” Climacteric, vol. 11, no. 2, pp. 166–174, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  53. J. Frisk, A. C. Spetz, H. Hjertberg, B. Petersson, and M. Hammar, “Two modes of acupuncture as a treatment for hot flashes in men with prostate cancer—a prospective multicenter study with long-term follow-up,” European Urology, vol. 55, no. 1, pp. 156–163, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  54. J. L. Tang, B. Y. Liu, and K. W. Ma, “Traditional Chinese medicine,” The Lancet, vol. 372, no. 9654, pp. 1938–1940, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  55. S. Knardahl, M. Elam, B. Olausson, and B. G. Wallin, “Sympathetic nerve activity after acupuncture in humans,” Pain, vol. 75, no. 1, pp. 19–25, 1998. View at Publisher · View at Google Scholar · View at Scopus
  56. L. A. Loaiza, S. Yamaguchi, M. Ito, and N. Ohshima, “Electro-acupuncture stimulation to muscle afferents in anesthetized rats modulates the blood flow to the knee joint through autonomic reflexes and nitric oxide,” Autonomic Neuroscience, vol. 97, no. 2, pp. 103–109, 2002. View at Publisher · View at Google Scholar · View at Scopus
  57. J. D. Wang, T. B. J. Kuo, and C. C. H. Yang, “An alternative method to enhance vagal activities and suppress sympathetic activities in humans,” Autonomic Neuroscience, vol. 100, no. 1-2, pp. 90–95, 2002. View at Publisher · View at Google Scholar · View at Scopus
  58. N. Kotani, H. Hashimoto, Y. Sato et al., “Preoperative intradermal acupuncture reduces postoperative pain, nausea and vomiting, analgesic requirement, and sympathoadrenal responses,” Anesthesiology, vol. 95, no. 2, pp. 349–356, 2001. View at Scopus
  59. A. Sato, Y. Sato, A. Suzuki, and S. Uchida, “Reflex modulation of catecholamine secretion and adrenal sympathetic nerve activity by acupuncture-like stimulation in anesthetized rat,” Japanese Journal of Physiology, vol. 46, no. 5, pp. 411–421, 1996. View at Publisher · View at Google Scholar · View at Scopus
  60. C. Carlsson, “Acupuncture mechanisms for clinically relevant long-term effects—reconsideration and a hypothesis,” Acupuncture in Medicine, vol. 20, no. 2-3, pp. 82–99, 2002. View at Scopus
  61. S. C. Pak, C. S. Na, J. S. Kirn et al., “The effect of acupuncture on uterine contraction induced by oxytocin,” American Journal of Chinese Medicine, vol. 28, no. 1, pp. 35–40, 2000. View at Scopus
  62. S. Andersson and T. Lundeberg, “Acupuncture—from empiricism to science functional background to acupuncture effects in pain and disease,” Medical Hypotheses, vol. 45, no. 3, pp. 271–281, 1995. View at Publisher · View at Google Scholar · View at Scopus
  63. R. S. S. Cheng and B. Pomeranz, “Monoaminergic mechanism of electroacupuncture analgesia,” Brain Research, vol. 215, no. 1-2, pp. 77–92, 1981. View at Scopus
  64. P. J. Goodnick, K. Breakstone, X. L. Wen, and A. Kumar, “Acupuncture and neuropathy,” American Journal of Psychiatry, vol. 157, no. 8, pp. 1342–1343, 2000. View at Publisher · View at Google Scholar · View at Scopus
  65. I. L. Bonta, “Acupuncture beyond the endorphin concept?” Medical Hypotheses, vol. 58, no. 3, pp. 221–224, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  66. Y. S. Son, H. J. Park, O. B. Kwon, S. C. Jung, H. C. Shin, and S. Lim, “Antipyretic effects of acupuncture on the lipopolysaccharide-induced fever and expression of interleukin-6 and interleukin-1β mRNAs in the hypothalamus of rats,” Neuroscience Letters, vol. 319, no. 1, pp. 45–48, 2002. View at Publisher · View at Google Scholar · View at Scopus
  67. Z. F. Xu, G. C. Wu, and X. D. Cao, “Effect of electroacupuncture on the expression of interlukin-1 β mRNA after transient focal cerebral ischemia,” Acupuncture and Electro-Therapeutics Research, vol. 27, no. 1, pp. 29–35, 2002. View at Scopus
  68. H. M. Langevin and P. D. Vaillancourt, “Acupuncture: does it work and, if so, how?” Seminars in Clinical Neuropsychiatry, vol. 4, no. 3, pp. 167–175, 1999. View at Scopus
  69. H. M. Langevin, D. L. Churchill, J. Wu et al., “Evidence of connective tissue involvement in acupuncture,” The FASEB Journal, vol. 16, no. 8, pp. 872–874, 2002. View at Scopus
  70. J. S. Han, “Acupuncture and endorphins,” Neuroscience Letters, vol. 361, no. 1–3, pp. 258–261, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  71. T. Yano, B. Kato, F. Fukuda et al., “Alterations in the function of cerebral dopaminergic and serotonergic systems following electroacupuncture and moxibustion applications: possible correlates with their antistress and psychosomatic actions,” Neurochemical Research, vol. 29, no. 1, pp. 283–293, 2004. View at Publisher · View at Google Scholar · View at Scopus
  72. H. Kashiba and Y. Ueda, “Acupuncture to the skin induces release of substance P and calcitonin gene-related peptide from peripheral terminals of primary sensory neurons in the rat,” American Journal of Chinese Medicine, vol. 19, no. 3-4, pp. 189–197, 1991. View at Scopus
  73. T. Lundeberg, “Electrical stimulation techniques,” Lancet, vol. 348, no. 9043, pp. 1672–1673, 1996. View at Scopus
  74. A. Sato, Y. Sato, M. Shimura, and S. Uchida, “Calcitonin gene-related peptide produces skeletal muscle vasodilation following antidromic stimulation of unmyelinated afferents in the dorsal root in rats,” Neuroscience Letters, vol. 283, no. 2, pp. 137–140, 2000. View at Publisher · View at Google Scholar
  75. H. M. Langevin, P. M. Wayne, H. MacPherson et al., “Paradoxes in acupuncture research: strategies for moving forward,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 180805, 11 pages, 2011. View at Publisher · View at Google Scholar · View at PubMed
  76. M. Thomas and T. Lundberg, “Importance of modes of acupuncture in the treatment of chronic nociceptive low back pain,” Acta Anaesthesiologica Scandinavica, vol. 38, no. 1, pp. 63–69, 1994.
  77. E. Haker and T. Lundeberg, “Acupuncture treatment in epicondylalgia: a comparative study of two acupuncture techniques,” Clinical Journal of Pain, vol. 6, no. 3, pp. 221–226, 1990. View at Scopus
  78. Z. L. Guo, A. R. Moazzami, S. Tjen-A-Looi, and J. C. Longhurst, “Responses of opioid and serotonin containing medullary raphe neurons to electroacupuncture,” Brain Research, vol. 1229, pp. 125–136, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  79. P. Li and J. C. Longhurst, “Neural mechanism of electroacupuncture's hypotensive effects,” Autonomic Neuroscience, vol. 157, no. 1-2, pp. 24–30, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  80. A. Moazzami, S. C. Tjen-A-Looi, Z. L. Guo, and J. C. Longhurst, “Serotonergic projection from nucleus raphe pallidus to rostral ventrolateral medulla modulates cardiovascular reflex responses during acupuncture,” Journal of Applied Physiology, vol. 108, no. 5, pp. 1336–1346, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  81. J. F. D'Amico, G. A. Greendale, J. K. H. Lu, and H. L. Judd, “Induction of hypothalamic opioid activity with transdermal estradiol administration in postmenopausal women,” Fertility and Sterility, vol. 55, no. 4, pp. 754–758, 1991. View at Scopus
  82. G. B. Melis, A. M. Paoletti, and M. Gambacciani, “Evidence that estrogens inhibit LH secretion through opioids in postmenopausal women using naloxone,” Neuroendocrinology, vol. 39, no. 1, pp. 60–63, 1984. View at Scopus
  83. K. K. S. Hui, O. Marina, J. Liu, B. R. Rosen, and K. K. Kwong, “Acupuncture, the limbic system, and the anticorrelated networks of the brain,” Autonomic Neuroscience, vol. 157, no. 1-2, pp. 81–90, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  84. Y. Wyon, K. Wijma, E. Nedstrand, and M. Hammar, “A comparison of acupuncture and oral estradiol treatment of vasomotor symptoms in postmenopausal women,” Climacteric, vol. 7, no. 2, pp. 153–164, 2004. View at Publisher · View at Google Scholar · View at Scopus
  85. K. Streitberger and J. Kleinhenz, “Introducing a placebo needle into acupuncture research,” Lancet, vol. 352, no. 9125, pp. 364–365, 1998. View at Publisher · View at Google Scholar · View at Scopus
  86. G. Goddard, Y. Shen, B. Steele, and N. Springer, “A controlled trial of placebo versus real acupuncture,” Journal of Pain, vol. 6, no. 4, pp. 237–242, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  87. P. White, G. Lewith, V. Hopwood, and P. Prescott, “The placebo needle, is it a valid and convincing placebo for use in acupuncture trials? A randomised, single-blind, cross-over pilot trial,” Pain, vol. 106, no. 3, pp. 401–409, 2003. View at Publisher · View at Google Scholar · View at Scopus
  88. H. Tsukayama, H. Yamashita, T. Kimura, and K. Otsuki, “Factors that influence the applicability of sham needle in acupuncture trials: two randomized, single-blind, crossover trials with acupuncture- experienced subjects,” Clinical Journal of Pain, vol. 22, no. 4, pp. 346–349, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  89. M. S. Lee, B. C. Shin, and E. Ernst, “Acupuncture for treating menopausal hot flushes: a systematic review,” Climacteric, vol. 12, no. 1, pp. 16–25, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  90. S. D. Brain and A. D. Grant, “Vascular actions of calcitonin gene-related peptide and adrenomedullin,” Physiological Reviews, vol. 84, no. 3, pp. 903–934, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  91. P. Holzer, “Neurogenic vasodilatation and plasma leakage in the skin,” General Pharmacology, vol. 30, no. 1, pp. 5–11, 1998. View at Publisher · View at Google Scholar · View at Scopus
  92. T. Schlereth, J. O. Dittmar, B. Seewald, and F. Birklein, “Peripheral amplification of sweating—a role for calcitonin gene-related peptide,” Journal of Physiology, vol. 576, no. 3, pp. 823–832, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  93. D. R. Poyner, “Calcitonin gene-related peptide: multiple actions, multiple receptors,” Pharmacology and Therapeutics, vol. 56, no. 1, pp. 23–51, 1992. View at Scopus
  94. D. Van Rossum, U. K. Hanisch, and R. Quirion, “Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors,” Neuroscience and Biobehavioral Reviews, vol. 21, no. 5, pp. 649–678, 1997. View at Publisher · View at Google Scholar · View at Scopus
  95. E. Schulze, M. Witt, T. Fink, A. Hofer, and R. H. W. Funk, “Immunohistochemical detection of human skin nerve fibers,” Acta Histochemica, vol. 99, no. 3, pp. 301–309, 1997. View at Scopus
  96. D. R. Poyner, “Molecular pharmacology of receptors for calcitonin-gene-related peptide, amylin and adrenomedullin,” Biochemical Society Transactions, vol. 25, no. 3, pp. 1032–1036, 1997. View at Scopus
  97. S. D. Brain and H. Cambridge, “Calcitonin gene-related peptide: vasoactive effects and potential therapeutic role,” General Pharmacology, vol. 27, no. 4, pp. 607–611, 1996. View at Publisher · View at Google Scholar · View at Scopus
  98. S. C. Landis and J. R. Fredieu, “Coexistence of calcitonin gene-related peptide and vasoactive intestinal peptide in cholinergic sympathetic innervation of rat sweat glands,” Brain Research, vol. 377, no. 1, pp. 177–181, 1986. View at Scopus
  99. B. Lindh, J. M. Lundberg, T. Hokfelt, L. G. Elfvin, J. Fahrenkrug, and J. Fischer, “Coexistence of CGRP- and VIP-like immunoreactivities in a population of neurons in the cat stellate ganglia,” Acta Physiologica Scandinavica, vol. 131, no. 3, pp. 475–476, 1987. View at Scopus
  100. Y. Kashihara, M. Sakaguchi, and M. Kuno, “Axonal transport and distribution of endogenous calcitonin gene-related peptide in rat peripheral nerve,” Journal of Neuroscience, vol. 9, no. 11, pp. 3796–3802, 1989. View at Scopus
  101. E. Tanaka, S. Uchiyama, and S. Nakano, “Effects of calcitonin gene-related peptide and vasoactive intestinal peptide on nicotine-induced sweating in man,” Journal of the Autonomic Nervous System, vol. 30, no. 3, pp. 265–268, 1990. View at Publisher · View at Google Scholar
  102. H. A. Bull, J. Hothersall, N. Chowdhury, J. Cohen, and P. M. Dowd, “Neuropeptides induce release of nitric oxide from human dermal microvascular endothelial cells,” Journal of Investigative Dermatology, vol. 106, no. 4, pp. 655–660, 1996.
  103. C. Zancanaro, F. Merigo, C. Crescimanno, S. Orlandini, and A. Osculati, “Immunohistochemical evidence suggests intrinsic regulatory activity of human eccrine sweat glands,” Journal of Anatomy, vol. 194, no. 3, pp. 433–444, 1999. View at Publisher · View at Google Scholar · View at Scopus
  104. W. R. Kennedy, G. Wendelschafer-Crabb, and T. C. Brelje, “Innervation and vasculature of human sweat glands: an immunohistochemistry-laser scanning confocal fluorescence microscopy study,” Journal of Neuroscience, vol. 14, no. 11, pp. 6825–6833, 1994.
  105. A. Kobayashi, T. Osaka, Y. Namba, S. Inoue, and S. Kimura, “CGRP microinjection into the ventromedial or dorsomedial hypothalamic nucleus activates heat production,” Brain Research, vol. 827, no. 1-2, pp. 176–184, 1999. View at Publisher · View at Google Scholar · View at Scopus
  106. A. Kobayashi, T. Osaka, Y. Namba, S. Inoue, and S. Kimura, “Involvement of sympathetic activation and brown adipose tissue in calcitonin gene-related peptide-induced heat production in the rat,” Brain Research, vol. 849, no. 1-2, pp. 196–202, 1999. View at Publisher · View at Google Scholar
  107. S. D. Brain, T. J. Williams, and J. R. Tippins, “Calcitonin gene-related peptide is a potent vasodilator,” Nature, vol. 313, no. 5997, pp. 54–56, 1985.
  108. T. J. Williams, S. D. Brain, P. G. Hellewell, P. J. Jose, S. Nourshargh, and M. Rampart, “Alteration in microvascular permeability induced by products released during inflammation,” Progress in Clinical and Biological Research, vol. 263, pp. 55–69, 1988. View at Scopus
  109. D. C. Braasch, E. M. Deegan, E. R. Grimm, and J. D. Griffin, “Calcitonin gene-related peptide alters the firing rates of hypothalamic temperature sensitive and insensitive neurons,” BMC Neuroscience, vol. 9, article no. 64, 2008. View at Publisher · View at Google Scholar · View at PubMed
  110. D. L. Hay and D. R. Poyner, “Calcitonin gene-related peptide, adrenomedullin and flushing,” Maturitas, vol. 64, no. 2, pp. 104–108, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  111. S. S. Tie-Jun, Z. Xu, and T. Hökfelt, “The expression of calcitonin gene-related peptide in dorsal horn neurons of the mouse lumbar spinal cord,” NeuroReport, vol. 12, no. 4, pp. 739–743, 2001. View at Scopus
  112. A. Blomqvist, “Colocalization of oestrogen receptor immunoreactivity and preprpenkephalin mRNA expression to neurons in the superficial laminae of the spinal and medullary dorsal horn of rats,” European Journal of Neuroscience, vol. 8, no. 11, pp. 2440–2445, 1996.
  113. A. Amandusson, M. Hallbeck, A.-L. Hallbeck, O. Hermanson, and A. Blomqvist, “Estrogen-induced alterations of spinal cord enkephalin gene expression,” Pain, vol. 83, no. 2, pp. 243–248, 1999. View at Publisher · View at Google Scholar
  114. M. Pohl, M. C. Lombard, S. Bourgoin et al., “Opioid control of the in vitro release of calcitonin gene-related peptide from primary afferent fibres projecting in the rat cervical cord,” Neuropeptides, vol. 14, no. 3, pp. 151–159, 1989. View at Scopus
  115. E. Collin, D. Frechilla, M. Pohl et al., “Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivo,” Brain Research, vol. 609, no. 1-2, pp. 211–222, 1993. View at Scopus
  116. D. Shoupe, F. J. Montz, and R. A. Lobo, “The effects of estrogen and progestin on endogenous opioid activity in oophorectomized women,” Journal of Clinical Endocrinology and Metabolism, vol. 60, no. 1, pp. 178–183, 1985. View at Scopus
  117. J. A. Chowen, J. Argente, L. Vician, D. K. Clifton, and R. A. Steiner, “Pro-opiomelanocortin messenger RNA in hypothalamic neurons is increased by testosterone through aromatization to estradiol,” Neuroendocrinology, vol. 52, pp. 581–588, 1990.
  118. C. Nappi, F. Petraglia, A. Gambardella et al., “Relationship between cerebrospinal fluid β-endorphin and plasma pituitary-gonadal hormone levels in women,” Journal of Endocrinological Investigation, vol. 13, no. 2, pp. 149–153, 1990.
  119. N. Tomimatsu, S. Hashimoto, and K. Akasofu, “Effects of oestrogen on hypothalamic β-endorphin in ovariectomized and old rats,” Maturitas, vol. 17, no. 1, pp. 5–16, 1993.
  120. K. Yuri and M. Kawata, “Estrogen affects calcitonin gene-related peptide- and methionine-enkephalin-immunoreactive neuron in the female rat preoptic area,” Neuroscience Letters, vol. 169, no. 1-2, pp. 5–8, 1994. View at Publisher · View at Google Scholar · View at Scopus
  121. E. Theodorsson-Norheim, A. Hemsen, E. Brodin, and J. M. Lundberg, “Sample handling techniques when analyzing regulatory peptides,” Life Sciences, vol. 41, no. 7, pp. 845–848, 1987. View at Scopus
  122. T. Scholzen, C. A. Armstrong, N. W. Bunnett, T. A. Luger, J. C. Olerud, and J. E. Ansel, “Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems,” Experimental Dermatology, vol. 7, no. 2-3, pp. 81–96, 1998. View at Scopus
  123. M. Schäffer, T. Beiter, H. D. Becker, and T. K. Hunt, “Neuropeptides. Mediators of inflammation and tissue repair?” Archives of Surgery, vol. 133, no. 10, pp. 1107–1116, 1998. View at Publisher · View at Google Scholar · View at Scopus
  124. R. Mentlein and T. Roos, “Proteases involved in the metabolism of angiotensin II, bradykinin, calcitonin gene-related peptide (CGRP), and neuropeptide Y by vascular smooth muscle cells,” Peptides, vol. 17, no. 4, pp. 709–720, 1996. View at Publisher · View at Google Scholar · View at Scopus
  125. Y. Wyon, A.-C. Spetz, M. Hammar, E. Theodorsson, and E. Varenhorst, “Urinary excretion of calcitonin gene-related peptide in males with hot flushes after castration for carcinoma of the prostate,” Scandinavian Journal of Urology and Nephrology, vol. 35, no. 2, pp. 92–96, 2001. View at Publisher · View at Google Scholar
  126. E. K. Borud, T. Alraek, A. White et al., “The Acupuncture on hot flushes among menopausal women (ACUFLASH) study, a randomized controlled trial,” Menopause, vol. 16, no. 3, pp. 484–493, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  127. C. M. Villalón and J. Olesen, “The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs,” Pharmacology and Therapeutics, vol. 124, no. 3, pp. 309–323, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  128. J. J. Lynch Jr., C. P. Regan, L. Edvinsson, R. J. Hargreaves, and S. A. Kane, “Comparison of the vasoconstrictor effects of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) and zolmitriptan in human isolated coronary arteries,” Journal of Cardiovascular Pharmacology, vol. 55, no. 5, pp. 518–521, 2010. View at Publisher · View at Google Scholar · View at PubMed
  129. L. Bai, J. Tian, C. Zhong et al., “Acupuncture modulates temporal neural responses in wide brain networks: evidence from fMRI study,” Molecular Pain, vol. 6, article no. 73, 2010. View at Publisher · View at Google Scholar · View at PubMed