Inhibition of Connexin 26/43 and Extracellular-Regulated Kinase Protein Plays a Critical Role in Melatonin Facilitated Gap Junctional Intercellular Communication in Hydrogen Peroxide-Treated HaCaT Keratinocyte Cells

<table>Chemical structure and cytotoxicity of melatonin. (a) Chemical structure of melatonin. Cytotoxicity of melatonin (b) and H<sub>2</sub>O<sub>2</sub> (c) in HaCaT cells. Cytotoxicity of melatonin and H<sub>2</sub>O<sub>2</sub> was evaluated in HaCaT cells by MTT assay. Cells were plated onto 96-well microplates (1 × 10<sup>4</sup> cells/well) and treated with various concentrations of melatonin (0, 0.25, 0.5, 1, 2, or 4 mM) and H<sub>2</sub>O<sub>2</sub> (0, 150, 300, or 600 <i>μ</i>M) for 24 h. Data were expressed as means ± SD of three independent experiments.</table>

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Figure 1

Figure 1: Inhibition of Connexin 26/43 and Extracellular-Regulated Kinase Protein Plays a Critical Role in Melatonin Facilitated Gap Junctional Intercellular Communication in Hydrogen Peroxide-Treated HaCaT Keratinocyte Cells 

Figure 1 | Inhibition of Connexin 26/43 and Extracellular-Regulated Kinase Protein Plays a Critical Role in Melatonin Facilitated Gap Junctional Intercellular Communication in Hydrogen Peroxide-Treated HaCaT Keratinocyte Cells 