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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 591654, 12 pages
Berberine in the Treatment of Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis
1Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
2Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
Received 23 May 2012; Accepted 23 July 2012
Academic Editor: Pierre Kamtchouing
Copyright © 2012 Hui Dong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [36 citations]
The following is the list of published articles that have cited the current article.
- Francesco Orio, Giovanna Muscogiuri, Stefano Palomba, Silvia Savastano, Alessio Volpe, Marcello Orio, Giorgio Colarieti, Giovanni Battista La Sala, Annamaria Colao, Francesca Marciano, Antonio Ascione, and Pietro Putignano, “Berberine improves reproductive features in obese Caucasian women with polycystic ovary syndrome independently of changes of insulin sensitivity,” e-SPEN Journal, 2013.
- Ki-Suk Kim, Hea Jung Yang, Eun-Kyeong Choi, Min Hee Shin, Kang-Hoon Kim, Jae Young Um, Byung-Cheol Lee, and Hyeung-Jin Jang, “The effects of complex herbal medicine composed of Cornus fructus, Dioscoreae rhizoma, Aurantii fructus, and Mori folium in obese type-2 diabetes mice model,” Oriental Pharmacy and Experimental Medicine, vol. 13, no. 1, pp. 69–75, 2013.
- Xiao-Jie Zhang, Yuan-Xiong Deng, Qun-Zhi Shi, Meng-Yun He, Bo Chen, and Xi-Min Qiu, “Hypolipidemic effect of the Chinese polyherbal Huanglian Jiedu decoction in type 2 diabetic rats and its possible mechanism,” Phytomedicine, 2013.
- Aa Izzo, “Chinese herbal formulation is safe and effective for type 2 diabetes,” Focus on Alternative and Complementary Therapies, vol. 18, no. 4, pp. 205–206, 2013.
- Sakshi Gupta, Nirmal Singh, and Amteshwar Singh Jaggi, “Alkaloids as Aldose Reductase Inhibitors, with Special Reference to Berberine,” The Journal of Alternative and Complementary Medicine, pp. 131115063425001, 2013.
- Jing Yao, WeiJia Kong, and JianDong Jiang, “Learning from berberine: Treating chronic diseases through multiple targets,” Science China Life Sciences, 2013.
- Yan Li, Hongying Kuang, Wenjuan Shen, Hongli Ma, Yuehui Zhang, Elisabet Stener-Victorin, Ernest Hung Yu Ng, Jianping Liu, Haixue Kuang, Lihui Hou, and Xiaoke Wu, “Letrozole, berberine, or their combination for anovulatory infertility in women with polycystic ovary syndrome: study design of a double-blind randomised controlled trial,” Bmj Open, vol. 3, no. 11, 2013.
- Cicero L. T. Chang, Yenshou Lin, Arlene P. Bartolome, Yi-Ching Chen, Shao-Chih Chiu, and Wen-Chin Yang, “Herbal Therapies for Type 2 Diabetes Mellitus: Chemistry, Biology, and Potential Application of Selected Plants and Compounds,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–33, 2013.
- Syed Ibrahim Rizvi, and Neetu Mishra, “Traditional Indian Medicines Used for the Management of Diabetes Mellitus,” Journal of Diabetes Research, vol. 2013, pp. 1–11, 2013.
- Rong-mei Liang, Xiao-lan Yong, Yu-qin Duan, Yong-hong Tan, Ping Zeng, Zi-ying Zhou, Yan Jiang, Shi-hua Wang, Yun-ping Jiang, Xiao-chun Huang, Zhao-hui Dong, Ting-ting Hu, Hui-qing Shi, and Nan Li, “Potent in vitro synergism of fusidic acid (FA) and berberine chloride (BBR) against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA),” World Journal of Microbiology and Biotechnology, 2014.
- Mohamed S. Othman, Gehan Safwat, Menna Aboulkhair, and Ahmed E. Abdel Moneim, “The Potential Effect of Berberine in Mercury-induced Hepatorenal Toxicity in Albino Rats,” Food and Chemical Toxicology, 2014.
- Keke Chen, Guohua Li, Fenghao Geng, Zhao Zhang, Jiani Li, Min Yang, Ling Dong, and Feng Gao, “Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K–Akt signaling in diabetic rats,” Apoptosis, 2014.
- Ming Chu, Ran Ding, Zheng-yun Chu, Ming-bo Zhang, Xiao-yan Liu, Shao-hua Xie, Yan-jun Zhai, and Yue-dan Wang, “Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4/MD-2 receptor,” Bmc Complementary and Alternative Medicine, vol. 14, 2014.
- Eric Yarnell, and Kathy Abascal, “Herbs for Diabetes: Update—Part 1,” Alternative and Complementary Therapies, vol. 20, no. 6, pp. 328–333, 2014.
- Jiarong Lan, Feixia Dong, Ziyou Yan, Wenjie Zheng, Jinping Fan, and Guoli Sun, “Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension,” Journal of Ethnopharmacology, 2014.
- Genoveva Berná, María Oliveras-López, Enrique Jurado-Ruíz, Juan Tejedo, Francisco Bedoya, Bernat Soria, and Franz Martín, “Nutrigenetics and Nutrigenomics Insights into Diabetes Etiopathogenesis,” Nutrients, vol. 6, no. 11, pp. 5338–5369, 2014.
- Mihwa Kwon, Young A. Choi, Min-Koo Choi, and Im-Sook Song, “Organic cation transporter-mediated drug–drug interaction potential between berberine and metformin,” Archives of Pharmacal Research, 2014.
- Zheng Li, Ya-Na Geng, Jian-Dong Jiang, and Wei-Jia Kong, “Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, pp. 1–12, 2014.
- Dan-Dan Zhao, Na Yu, Xiao-Ke Li, Xin Fang, Qian-qian Mu, Pei-Jie Qin, Yue Ma, Fang-Fang Mo, Dong-Wei Zhang, and Si-Hua Gao, “Antidiabetic and Antioxidative Effect of Jiang Tang Xiao Ke Granule in High-Fat Diet and Low-Dose Streptozotocin Induced Diabetic Rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, pp. 1–8, 2014.
- Hui Wang, Wei Mu, Hongcai Shang, Jia Lin, and Xiang Lei, “The Antihyperglycemic Effects of Rhizoma Coptidis and Mechanism of Actions: A Review of Systematic Reviews and Pharmacological Research,” BioMed Research International, vol. 2014, pp. 1–10, 2014.
- Angela Pirillo, and Alberico Luigi Catapano, “Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies,” Atherosclerosis, 2015.
- Jian-Ming He, and Qing Mu, “The medicinal uses of the genus Mahonia in traditional Chinese medicine: An ethnopharmacological, phytochemical and pharmacological review,” Journal of Ethnopharmacology, 2015.
- Wenxiao Jiang, Wenjie Wei, Marta A. Gaertig, Shihua Li, and Xiao-Jiang Li, “Therapeutic Effect of Berberine on Huntington's Disease Transgenic Mouse Model,” Plos One, vol. 10, no. 7, 2015.
- Si-Fan Sun, Ting-Ting Zhao, Hao-Jun Zhang, Xiao-Ru Huang, Wei-Ku Zhang, Lei Zhang, Mei-Hua Yan, Xi Dong, Hua Wang, Yu-Min Wen, Xin-Ping Pan, Hui Yao Lan, and Ping Li, “Renoprotective effect of berberine on type 2 diabetic nephropathy in rats,” Clinical and Experimental Pharmacology and Physiology, vol. 42, no. 6, pp. 662–670, 2015.
- Anil Kumar, Ekavali, Kanwaljit Chopra, Madhurima Mukherjee, Raghavender Pottabathini, and Dinesh K. Dhull, “Current knowledge and pharmacological profile of berberine: An update,” European Journal of Pharmacology, 2015.
- Juan Zheng, Shih-Lung Woo, Xiang Hu, Rachel Botchlett, Lulu Chen, Yuqing Huo, and Chaodong Wu, “Metformin and metabolic diseases: a focus on hepatic aspects,” Frontiers of Medicine, 2015.
- Giuseppina Guarino, Teresa Della Corte, Morena Sofia, Lucia Carbone, Giampiero Marino, Emilia Martedì, and Sandro Gentile, “Metabolic effects of the association Berberis aristata/Silybum marianum: a preliminary double-blind, placebo-controlled study in obese patients with type 2 diabetes,” Nutrafoods, 2015.
- Atul Luthra, and Anoop Misra, “The marketing of unproven drugs for diabetes and dyslipidaemia in India,” The Lancet Diabetes & Endocrinology, vol. 3, no. 10, pp. 758–760, 2015.
- Zhiping Wang, Junbiao Wu, Qun Zhou, Yifei Wang, and Tongsheng Chen, “Berberine Nanosuspension Enhances Hypoglycemic Efficacy on Streptozotocin Induced Diabetic C57BL/6 Mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, pp. 1–5, 2015.
- Yoon Sin Oh, “Plant-Derived Compounds Targeting Pancreatic Beta Cells for the Treatment of Diabetes,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, pp. 1–12, 2015.
- Bing Pang, Lin-Hua Zhao, Qiang Zhou, Tian-Yu Zhao, Han Wang, Cheng-Juan Gu, and Xiao-Lin Tong, “Application of Berberine on Treating Type 2 Diabetes Mellitus,” International Journal of Endocrinology, vol. 2015, pp. 1–12, 2015.
- Beniamino Pagliaro, Caterina Santolamazza, Francesca Simonelli, and Speranza Rubattu, “Phytochemical Compounds and Protection from Cardiovascular Diseases: A State of the Art,” BioMed Research International, vol. 2015, pp. 1–17, 2015.
- Xiao-Ke Wu, Yong-Yan Wang, Jian-Ping Liu, Rui-Ning Liang, Hui-Ying Xue, Hong-Xia Ma, Xiao-Guang Shao, and Ernest H.Y. Ng, “Randomized controlled trial of letrozole, berberine, or a combination for infertility in the polycystic ovary syndrome,” Fertility and Sterility, 2016.
- Yu Dong, Yi-Tao Chen, Yuan-Xiao Yang, Xiao-Jie Zhou, Shi-Jie Dai, Jun-Feng Tong, Dan Shou, and Changyu Li, “Metabolomics Study of Type 2 Diabetes Mellitus and the AntiDiabetic Effect of Berberine in Zucker Diabetic Fatty Rats Using Uplc-ESI-Hdms,” Phytotherapy Research, vol. 30, no. 5, pp. 823–828, 2016.
- Swagat Kumar Das, Luna Samanta, and Hrudayanath Thatoi, “ In Vitro A ntidiabetic and Antioxidant Potentials of Leaf and Stem Bark Extracts of a Mangrove Plant, Xylocarpus granatum ,” Journal of Herbs, Spices & Medicinal Plants, vol. 22, no. 2, pp. 105–117, 2016.
- Chang-Shun Liu, Yu-Rong Zheng, Ying-Feng Zhang, and Xiao-Ying Long, “Research progress on berberine with a special focus on its oral bioavailability,” Fitoterapia, 2016.