Evidence-Based Complementary and Alternative Medicine

Research Article

Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes

Table 1

Antimycobacterial and antiprotozoal activities of the hexanic extract and pure compounds isolated from A. elegans.


Sample	MIC (μg mL⁻¹) M. tuberculosis							IC₅₀ (μg mL⁻¹)
Sample	H37Rv	CIBIN/UMF15 : 99	SIN4	RIF-R	STR-R	INH-R	EMB-R	E. histolytica	G. lamblia

Hexanic extract	>100	50	50	ND	ND	ND	ND	0.235	0.315
Eupomatenoid-1	100	100	100	100	100	100	100	0.624	0.545
Fargesin	50	>100	50	25	25	12.5	>50	120.6	262.7
(8R,8′R,9R)-Cubebin	50	50	50	100	100	100	100	137.3	275.0
Rifampicin	0.06	>100	100	>25	0.06	0.06	0.06	—	—
Isoniazid	0.06	3.1	3.1	0.06	0.06	>25	0.06	—	—
Streptomycin	0.5	>100	>4	0.5	>8	0.5	0.5	—	—
Ethambutol	2.0	8	>16	1.0	1.0	1.0	>32	—	—
Ofloxacin	—	0.5	8.0	—	—	—	—	—	—
Metronidazole	—	—	—	—	—	—	—	0.060	0.210

H37Rv: sensitive strain to INH, RIF, EMB, STR, and pyrazinamide; CIBIN/UMF15:99: resistant strain to INH, RIF, EMB, STR, and pyrazinamide; SIN4: resistant strain to INH, RIF, EMB, STR, rifabutin, ethionamide, and ofloxacin; RIF-R: rifampicin-resistant; STR-R: streptomycin-resistant; INH-R: isoniazid-resistant and EMB-R: ethambutol-resistant. ND: no determined; MIC: minimum inhibitory concentration; IC₅₀: 50% inhibitory concentration. Data are means of three determinations.