Curcumin Protects against UVB-Induced Skin Cancers in SKH-1 Hairless Mouse: Analysis of Early Molecular Markers in Carcinogenesis

Figure 4

Effect of curcumin on UVB-induced p53 and p21/Cip1 expressions. CUR enhances UVB-induced p53 and p21/Cip1 expressions, left and right panels, respectively. (a) and (e) controls; (b) and (f) UV; (c) (g) CUR-T + UV. Arrows show p53-positive cells ((b) and (c)) or p21/Cip1-positive cells ((f) and (g)) with brown staining. (d) and (h) are the quantitative results of p53- and p21/Cip1-positive cells cell populations in five different experimental conditions, respectively. ^∗𝑃<0.004 (p53), ^∗𝑃<0.003 (p21/Cip1).