Inhibition of Advanced Glycation End-Product Formation by Origanum majorana L. In Vitro and in Streptozotocin-Induced Diabetic Rats

Table 4

Protective effect of 5 and 10 𝜇g/mL, of OM on LDL against 50 mM glucose-induced glycation and oxidation with or without 0.5 mM EDTA treatment.

Treatment	With EDTA		Without EDTA
	Glycation	Oxidation	Glycation	Oxidation
LDL	2.8±0.56	3.7±0.84	3.8±0.93	21.03±2.31
LDL + glucose	17.2 ± 3.19^a	4.3 ± 1.39^a	22.65 ± 3.28^a	58.80 ± 3.18^a
OM (5 𝜇g/ml)	5.4 ± 0.96^a,b	3.3 ± 0.57^b	15.14 ± 2.74^a,b	36.49 ± 4.35^a,b
OM (10 𝜇g/ml)	4.1 ± 0.74^b	2.9 ± 0.98^b	13.86 ± 2.52^a,b	31.83 ± 2.06^a,b

Values are expressed as Mean ± SD (𝑛=6), ^aSignificantly (𝑃<0.05) different from LDL group. ^bSignificantly (𝑃<0.05) different from LDL + glucose, where the significance was performed by oneway ANOVA followed by post hoc Dunnett’s test.