Involvement of Prohibitin Upregulation in Abrin-Triggered Apoptosis
Figure 1
Abrin (ABR) upregulates prohibitin (PHB) expression through transcriptional regulation in Jurkat T cells. (a) ABR-induced cytotoxic activity in a dose-dependent manner in Jurkat T cells after 24 h treatment. The data are represented as mean ± SD from 3 independent experiments. (b) ABR (0.1–10 nM) significantly increased the expression of PHB after treatment for 9 h. (c) ABR (1 nM)-induced upregulation of PHB in a time-dependent manner. (d) ABR-induced PHB upregulation requires de novo RNA synthesis.
