Involvement of Prohibitin Upregulation in Abrin-Triggered Apoptosis
Figure 2
The JNK/SAPK signaling pathway is required for abrin (ABR)-triggered upregulation of prohibitin (PHB). (a) Cells were treated with or without indicated inhibitors for 1 h before ABR treatment. Effects of PD98059 (PD; 20 μM), SB203580 (SB; 20 μM), or SP600125 (SP; 30 μM) on their target signaling molecules were shown. (b) Cells were pretreated with 20 μM PD, 20 μM SB, or 30 μM SP for 1 h before ABR treatment. After the indicated period of time, only SP significantly inhibited the upregulation of PHB by ABR as shown by western blot analysis.
