Involvement of Prohibitin Upregulation in Abrin-Triggered Apoptosis

Table 1

Top 10 up-/downregulated genes changing in response to abrin exposure arranged by fold change. Gene common name, description, and gene ontology classification (where known) are listed.

Unigene number	Common name	Description	Fold change	GO biological process	GO molecular function	GO cellular process
Upregulation
Hs.326035	EGR1	Early growth response 1	12.9	Transcription, DNA dependent	Transcription activator activity	Nucleus
Hs.502769	SLC3A2	Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	3.0	Transmembrane transport	Catalytic activity	Plasma membrane
Hs.2178	HIST2H2BE	Histone cluster 2, H2be	2.5	Nucleosome assembly	Binding to DNA and protein	Nucleus
Hs.82963	GNRH1	Gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	2.4	Multicellular organismal development	Hormone activity	Extracellular
Hs.467408	TRIM28	Tripartite motif-containing 28	2.3	Transcription, DNA dependent	Transcription coactivator/corepressor activity	Nucleus
Hs.514303	PHB	Prohibitin	2.3	Negative regulation of cell proliferation, gene-specific transcription from RNA polymerase II promoter by competitive promoter binding; regulation of apoptosis; signal transduction	Transcription activator/repressor activity	Cytoplasma, plasma membrane, mitochondria, nucleus
Hs.534404	RPL10	Ribosomal protein L10	2.2	Translation	Structural constituent of ribosome	Cytosol
Hs.5120	DYNLL1	Dynein, light chain, LC8-type 1	2.2	Induction of apoptosis	Motor activity	Cytosol
Hs.226390	RRM2	Ribonucleotide reductase M2	2.1	DNA replication	Oxidoreductase activity	Cytosol
Hs.202207	OSCP1	Organic solute carrier partner 1	2.1	Transport		Plasma membrane
Hs.25524	PTPN23	Protein tyrosine phosphatase, nonreceptor type 23	2.1	Cell projection organization	Hydrolase activity	Cytoplasma
Downregulation
Hs.725987	TUBA1C	Tubulin, alpha 1c	−1.8	Cellular protein metabolic process	Structural molecule activity	Cytosol
Hs.535192	EEF1A1	Eukaryotic translation elongation factor 1 alpha 1	−1.6	Translation	Translation elongation factor activity	Cytosol
Hs.514581	ACTG1	Actin, gamma 1	−1.6	Cellular component movement	Protein binding	Cytosol
Hs.5662	GNB2L1	Guanine nucleotide-binding protein (G protein), beta polypeptide 2-like 1	−1.5	Positive regulation of apoptosis	Protein binding	Cytosol
Hs.534346	RPS7	Ribosomal protein S7	−1.5	Translation	Structural constituent of ribosome	Cytosol
Hs.433427	RPS17	Ribosomal protein S17	−1.5	Translation	Structural constituent of ribosome	Cytosol
Hs.5662	GNB2L1	Guanine nucleotide-binding protein (G protein), beta polypeptide 2-like 1	−1.5	Negative regulation of cell growth	Protein binding	Nucleus, cytosol
Hs.444467	EEF1G	Eukaryotic translation elongation factor 1 gamma	−1.5	Translational elongation	Translation elongation factor activity	Cytosol
Hs.514581	ACTG1	Actin, gamma 1	−1.5	Cellular component movement	Structural constituent of cytoskeleton	Cytosol
Hs.509736	HSP90AB1	Heat shock protein 90 kDa alpha (cytosolic), class B member 1	−1.5	Regulation of type I interferon-mediated signaling pathway	Unfolded protein binding	Cytosol