From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound

<table>MPTP induces deficit of swimming behavior in zebrafish. (a) Typical swimming patterns of control and MPTP-treated zebrafish. Lines show the track of zebrafish movement. Zebrafish treated with MPTP was less active as compared to the control. (b) Quantitative analysis of total distance travelled. <svg height="15.775" id="M7" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 67.387497 15.775" width="67.387497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared with untreated control. <svg height="13.95" id="M8" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared with MPTP treated alone.</table>

Evidence-Based Complementary and Alternative Medicine

fig6

Figure 6

Figure 6: From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound 