From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound

<table>Sutent-induced cardiotoxicity in zebrafish embryos. Embryos at 5 dpf were treated with Sutent for 72 h followed by assessment of cardiac function. (a) Pericardial edema was observed after administration of Sutent compared to the control. The severity of pericardial edema was quantified by measuring the distance between sinus venosus (SV) and bulbus arteriosus (BA). (b) Embryo heart rate was decreased by treatment with Sutent in dose-dependent manner.</table>

Evidence-Based Complementary and Alternative Medicine

fig7

Figure 7

Figure 7: From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound 