From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound

Figure 8

Atorvastatin-induced cerebral hemorrhage in zebrafish embryos. Tg(fli1:EGFP); Tg(gata1:dsred) homozygous double transgenic zebrafish embryos at 24 hpf were treated with atorvastatin alone or with atorvastatin and mevalonate (MEV) in combination for 24 h. Images showing blood vessels (EGFP, green) were superimposed on images showing blood flow (DsRed, red). Hemorrhage observed in the atorvastatin treatment group was prevented by cotreatment with MEV. Fluorescent microscopic images are at magnification 100x.

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