From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound

Table 1

Discrepancies and similarities of the effect of drugs in human and zebrafish.

Area of evaluation in zebrafish	Test compounds	Proportion of drugs with expected effects (%)	Reference
Inhibition of hERG or QTc prolongation	Study 1: Amiodarone, bepridil, cisapride, haloperidol, pimozide, procainamide, D,L-sotalol, terfenadine, thioridazine	All compounds, except for procainamide	[3]
	Study 2: Negative controls: amoxicillin, aspirin; Positive controls: chlorpromazine, cisapride, cromakalim, isoprenaline, moxifloxacin, nicotine, verapamil	7 out of 9 compounds, including negative controls	[1]
Visual safety or optomotor response	Study 1: 27 compounds, including 19 with positive and 8 with negative effects on inhibition of optomotor response	About 70% in overall showed the predicted drug effects.	[4]
	Study 2: Negative control: aspirin; Positive controls: chloroquine, chlorpromazine, diazepam, nicotine, ouabain, phenytoin, atropine, lithium	7 out of 9 compounds including negative control	[1]
Seizure liability	25 drugs including 17 positive and 8 negative controls	72% in overall	[5]
Gut contraction	Negative controls: aspirin and moxifloxacin; Positive controls: amoxicillin, chlorpromazine, cisapride, cromakalim, isoprenaline, nicotine, nitrendipine, and verapamil	5 out of 10 compounds including negative controls	[1]