Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity

Table 4

Histopathological cardiac changes in animals exposed to doxorubicin (DOX) with or without resveratrol (RV).

	𝑛	Eosinophilic degeneration	Parenchymatous degeneration	Vacuolar degeneration	Irregular direction of cardiomyocytes	Pycnotic nuclei of cardiomyocytes	Interstitial edema	Necrosis	Inflammatory; infiltration
Control	8	0	1	0	3	0	1	0/0^a	0/0^b
1DOX	6	2	3	2	3	1	3	0/4	0/4
1DOX + RV	6	4	4	1	5	0	2	0/2	0/2
2DOX	6	6	4	3	5	2	5	4/2	4/2
2DOX + RV	6	3	2	4	3	2	1	1/3	1/4

A single animal may be represented more than once in the listing of individual histological changes.
^aMassive necrosis/changes limited to individual cardiomyocytes.
^bMassive inflammatory infiltration/disseminate mononuclear cells between cardiomyocytes.