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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 607517, 6 pages
http://dx.doi.org/10.1155/2012/607517
Research Article

Mozart K.545 Mimics Mozart K.448 in Reducing Epileptiform Discharges in Epileptic Children

1Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City 807, Taiwan
2Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City 807, Taiwan
3Department of Music, National Sun Yat-Sen University, Kaohsiung City 804, Taiwan
4Institute of Applied Physics and Underseas Technology, National Sun Yat-Sen University, Kaohsiung City 804, Taiwan
5Institute of Marine Biology, National Sun Yat-Sen University, Kaohsiung City 804, Taiwan
6Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung City 807, Taiwan

Received 8 May 2012; Accepted 11 November 2012

Academic Editor: R. Govindarajan

Copyright © 2012 Lung-Chang Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mozart K.448 has been shown to improve cognitive function, leading to what is known as the Mozart Effect. Our previous work reveals positive effects of Mozart K.448 in reducing epileptiform discharges in epileptic children. In this study, we evaluated the effect of Mozart K.545 and compared the effects with those of Mozart K.448 on epileptiform discharges in children with epilepsy. Thirty-nine epileptic children with epileptiform discharges were included in the study. They received electroencephalogram examinations before, during, and after listening to Mozart K.448 and K.545, one week apart, respectively. The frequencies of epileptiform discharges were compared. There was a significant decrease in the frequency of epileptiform discharges during and right after listening to Mozart K.448 and K.545 (reduced by % during Mozart K.448 and % after Mozart K.448; and % during Mozart K.545 and % after Mozart K.545). Spectrogrammatic analysis of the two pieces of music demonstrated that both share similar spectrogrammatic characteristics. Listening to Mozart K.448 and K.545 decreased the epileptiform discharges in epileptic children. This suggests that Mozart K.448 is not the only piece of music to have beneficial effects on children with epilepsy. Other music with lower harmonics may also decrease epileptiform discharges in epileptic children.