Acute and 28-Day Subchronic Oral Toxicity of an Ethanol Extract of Zingiber zerumbet (L.) Smith in Rodents

Table 1

Effects of subchronic oral administration of the ethanol extract of Z. zerumbet rhizomes (EEZZ) on body weight, food and water intakes in Wistar rats.

Week (W) of Treatment	Female				Male
	Vehicle	EEZZ (mg kg^−1 per day)			Vehicle	EEZZ (mg kg^−1 per day)
		1000	2000	3000		1000	2000	3000
Body weight (g)
W1	212.97 ± 15.97	214.83 ± 13.42	215.32 ± 16.41	218.92 ± 13.56	223.61 ± 16.48	225.58 ± 14.59	229.26 ± 16.41	228.12 ± 15.92
W2	229.60 ± 14.75	224.67 ± 14.87	219.83 ± 19.26	223.97 ± 16.92	241.08 ± 15.24	235.90 ± 16.11	241.81 ± 13.88	246.37 ± 19.61
W3	245.11 ± 17.36	249.32 ± 15.96	233.51 ± 13.88	241.28 ± 15.86	257.36 ± 17.91	261.78 ± 17.26	256.68 ± 19.26	265.41 ± 20.15
W4	244.72 ± 12.63	245.21 ± 17.81	237.72 ± 14.72	243.81 ± 17.41	256.96 ± 13.08	257.47 ± 18.90	261.49 ± 14.72	268.19 ± 18.44
Food intake (g day^−1 per rat)
W1	22.86 ± 4.04	25.95 ± 3.01	25.29 ± 2.84	24.66 ± 3.12	24.13 ± 4.13	26.23 ± 3.47	26.36 ± 4.15	26.17 ± 4.21
W2	20.31 ± 3.69	22.25 ± 2.94	21.62 ± 3.14	20.44 ± 3.68	23.16 ± 4.45	23.32 ± 4.17	23.52 ± 3.69	23.52 ± 3.68
W3	22.40 ± 3.87	20.83 ± 3.74	21.11 ± 3.49	21.45 ± 4.95	23.21 ± 4.17	22.39 ± 3.49	22.32 ± 4.18	23.58 ± 3.95
W4	19.70 ± 3.94	20.59 ± 4.78	21.70 ± 4.32	20.97 ± 3.34	20.08 ± 3.62	21.74 ± 3.35	22.58 ± 3.93	23.14 ± 4.87
Water intake (ml day^−1 per rat)
W1	24.12 ± 5.62	25.63 ± 6.25	24.08 ± 6.61	24.37 ± 5.12	25.32 ± 6.18	26.38 ± 6.38	25.28 ± 7.41	25.37 ± 6.12
W2	25.09 ± 8.61	25.82 ± 5.61	24.62 ± 7.92	24.19 ± 6.83	26.34 ± 9.47	26.11 ± 6.15	25.85 ± 6.76	25.91 ± 7.38
W3	26.17 ± 5.09	25.56 ± 6.52	26.51 ± 8.12	23.82 ± 7.14	27.47 ± 5.59	26.83 ± 5.28	27.83 ± 7.31	26.27 ± 8.01
W4	24.41 ± 4.97	24.09 ± 5.18	25.41 ± 6.34	25.43 ± 7.27	25.63 ± 5.47	25.29 ± 5.18	25.41 ± 8.12	25.96 ± 6.98

Wistar rats (n = 10 per group) were administered ZZEE by daily gavage for 4 weeks. Data are expressed as mean ± SD.