Acute and 28-Day Subchronic Oral Toxicity of an Ethanol Extract of Zingiber zerumbet (L.) Smith in Rodents

Table 2

Effects of subchronic oral administration of the ethanol extract of Z. zerumbet rhizomes (EEZZ) on haematological parameters of Wistar rats.

Parameters	Female				Male
	Vehicle	EEZZ (mg kg^−1 per day)			Vehicle	EEZZ (mg kg^−1 per day)
		1000	2000	3000		1000	2000	3000
WBC (10^3 𝜇L^−1)	9.09 ± 0.59	8.69 ± 0.62	8.78 ± 0.57	8.61 ± 0.64	9.20 ± 0.68	8.90 ± 0.70	8.59 ± 0.73	8.76 ± 0.64
Lymphocytes (10^3 𝜇L^−1)	6.76 ± 0.40	6.66 ± 0.65	6.58 ± 0.35	7.14 ± 0.65	6.92 ± 0.75	7.36 ± 0.63	7.52 ± 0.60	7.86 ± 0.71
Erythrocytes (10^6 𝜇L^−1)	7.29 ± 0.07	7.69 ± 0.10	7.70 ± 0.08	7.76 ± 0.11	7.43 ± 0.11	7.34 ± 0.09	7.37 ± 0.08	7.46 ± 0.10
Hemoglobin (g dL^−1)	16.28 ± 0.18	16.36 ± 0.17	16.29 ± 0.14	16.47 ± 0.17	17.97 ± 0.24	17.72 ± 0.18	17.48 ± 0.16	17.59 ± 0.23
Hematocrit (%)	41.17 ± 0.25	42.93 ± 0.21	43.29 ± 0.19	43.14 ± 0.21	42.53 ± 0.26	40.28 ± 0.31	40.51 ± 0.29	40.94 ± 0.23
MCV (fL)	52.14 ± 0.32	52.26 ± 0.28	50.13 ± 0.29	51.97 ± 0.32	50.35 ± 0.29	51.91 ± 0.25	52.76 ± 0.27	49.55 ± 0.23
MCH (pg)	18.86 ± 0.13	19.49 ± 0.19	20.56 ± 0.12	19.43 ± 0.12	19.85 ± 0.19	19.81 ± 0.18	19.78 ± 0.16	19.31 ± 0.17
MCHC (g dL^−1)	35.43 ± 0.31	35.62 ± 0.42	35.57 ± 0.38	35.76 ± 0.29	35.30 ± 0.25	36.07 ± 0.33	36.04 ± 0.27	36.01 ± 0.27
RDW (%)	12.12 ± 0.15	12.15± 0.16	12.16 ± 0.14	12.15 ± 0.17	17.04 ± 0.13	17.10 ± 0.12	17.55 ± 0.13	17.57 ± 0.17
Platelets (10^3 𝜇L^−1)	647.54 ± 26.98	626.31 ± 25.23	665.08 ± 28.80	642.08 ± 32.44	679.54 ± 37.73	611.85 ± 39.58	619.09 ± 25.29	606.15 ± 28.31
MPV (fL)	6.08 ± 0.18	5.90 ± 0.08	5.89 ± 0.06	5.88 ± 0.08	5.48 ± 0.09	5.21 ± 0.08	5.29 ± 0.10	5.29 ± 0.07

Wistar rats (n = 10 per group) were administered ZZEE by daily gavage for 4 weeks. Data are expressed as mean ± SD.