Acute and 28-Day Subchronic Oral Toxicity of an Ethanol Extract of Zingiber zerumbet (L.) Smith in Rodents

Table 4

Effects of subchronic oral administration of the ethanol extract of Z. zerumbet rhizomes (EEZZ) on organ weights of female Wistar rats.

Organs	Organ weight (g)				Relative organ weight (g 100 g^−1 of body weight)
	Vehicle	EEZZ (mg kg^−1 per day)			Vehicle	EEZZ (mg kg^−1 per day)
		1000	2000	3000		1000	2000	3000
Spleen	0.445 ± 0.028	0.436 ± 0.031	0.456 ± 0.027	0.454 ± 0.027	0.182 ± 0.011	0.178 ± 0.018	0.184 ± 0.013	0.186 ± 0.012
Brain	1.111 ± 0.026	1.124 ± 0.030	1.097 ± 0.027	1.116 ± 0.031	0.454 ± 0.019	0.458 ± 0.015	0.443 ± 0.014	0.458 ± 0.016
Heart	0.853 ± 0.018	0.847 ± 0.023	0.825 ± 0.025	0.860 ± 0.019	0.349 ± 0.014	0.345 ± 0.017	0.333 ± 0.011	0.353 ± 0.009
Esophagus	0.093 ± 0.002	0.088 ± 0.003	0.093 ± 0.003	0.093 ± 0.002	0.038 ± 0.003	0.036 ± 0.002	0.038 ± 0.002	0.039 ± 0.004
Stomach	1.385 ± 0.027	1.369 ± 0.026	1.371 ± 0.031	1.379 ± 0.029	0.566 ± 0.013	0.558 ± 0.017	0.553 ± 0.015	0.566 ± 0.016
Liver	8.631 ± 0.048	8.633 ± 0.052	8.523 ± 0.046	8.651 ± 0.061	3.527 ± 0.017	3.520 ± 0.022	3.441 ± 0.019	3.548 ± 0.021
Adrenal gland	0.023 ± 0.002	0.025 ± 0.001	0.026 ± 0.002	0.029 ± 0.002	0.009 ± 0.001	0.010 ± 0.002	0.010 ± 0.003	0.011 ± 0.002
Hypophysis	0.004 ± 0.002	0.004 ± 0.001	0.004 ± 0.001	0.004 ± 0.001	0.001 ± 0.001	0.001 ± 0.001	0.001 ± 0.001	0.001 ± 0.001
Hypothalamus	0.027 ± 0.002	0.028 ± 0.001	0.029 ± 0.001	0.027 ± 0.002	0.011 ± 0.003	0.011 ± 0.002	0.011 ± 0.001	0.012 ± 0.003
Small intestine	0.516 ± 0.021	0.525 ± 0.018	0.515 ± 0.019	0.521 ± 0.022	0.211 ± 0.009	0.214 ± 0.008	0.208 ± 0.007	0.214 ± 0.009
Lungs	1.309 ± 0.053	1.278 ± 0.046	1.308 ± 0.055	1.320 ± 0.043	0.535 ± 0.017	0.521 ± 0.014	0.528 ± 0.019	0.541 ± 0.022
Kidney	0.859 ± 0.029	0.867 ± 0.034	0.874 ± 0.045	0.864 ± 0.037	0.351 ± 0.018	0.354 ± 0.019	0.353 ± 0.017	0.355 ± 0.020
Ovary	0.044 ± 0.003	0.043 ± 0.003	0.042 ± 0.002	0.042 ± 0.002	0.018 ± 0.002	0.017 ± 0.002	0.017 ± 0.003	0.017 ± 0.002
Uterus	0.546 ± 0.026	0.566 ± 0.029	0.574 ± 0.031	0.551 ± 0.039	0.223 ± 0.022	0.230 ± 0.026	0.231 ± 0.025	0.226 ± 0.025

Wistar rats (n = 10 per group) were administered EEZZ by daily gavage for 4 weeks. Data are expressed as mean ± SD.