Acute and 28-Day Subchronic Oral Toxicity of an Ethanol Extract of Zingiber zerumbet (L.) Smith in Rodents

Table 5

Effect of subchronic oral administration of the ethanol extract of Z. zerumbet rhizomes (EEZZ) on organ weights of male Wistar rats.

Organs	Organ weight (g)				Relative organ weight (g 100 g^−1 of body weight)
	Vehicle	EEZZ (mg kg^−1 per day)			Vehicle	EEZZ (mg kg^−1 per day)
		1000	2000	3000		1000	2000	3000
Spleen	0.591 ± 0.038	0.571 ± 0.041	0.599 ± 0.039	0.585 ± 0.043	0.230 ± 0.012	0.222 ± 0.009	0.229 ± 0.011	0.218 ± 0.013
Brain	1.188 ± 0.015	1.197 ± 0.017	1.198 ± 0.018	1.171 ± 0.021	0.464 ± 0.022	0.466 ± 0.027	0.459 ± 0.019	0.437 ± 0.023
Heart	1.083 ± 0.048	1.072 ± 0.039	1.074 ± 0.043	1.086 ± 0.047	0.427 ± 0.009	0.330 ± 0.016	0.319 ± 0.013	0.282 ± 0.018
Esophagus	0.133 ± 0.010	0.127 ± 0.009	0.122 ± 0.011	0.130 ± 0.008	0.423 ± 0.008	0.049 ± 0.011	0.046 ± 0.009	0.049 ± 0.013
Stomach	1.438 ± 0.038	1.482 ± 0.045	1.453± 0.047	1.461 ± 0.041	0.561 ± 0.021	0.577 ± 0.019	0.556 ± 0.023	0.546 ± 0.021
Liver	9.971 ± 0.035	9.952 ± 0.043	9.986 ± 0.048	9.994 ± 0.052	3.894 ± 0.118	3.872 ± 0.153	3.826 ± 0.175	3.729 ± 0.143
Adrenal gland	0.024 ± 0.002	0.025 ± 0.001	0.021 ± 0.003	0.023 ± 0.003	0.009 ± 0.003	0.009 ± 0.002	0.008 ± 0.002	0.009 ± 0.003
Hypophysis	0.004 ± 0.001	0.004 ± 0.001	0.004 ± 0.001	0.004 ± 0.001	0.001 ± 0.001	0.001 ± 0.001	0.001 ± 0.001	0.001 ± 0.001
Hypothalamus	0.036 ± 0.001	0.035 ± 0.001	0.035 ± 0.001	0.034 ± 0.001	0.014 ± 0.002	0.014 ± 0.001	0.013 ± 0.001	0.013 ± 0.002
Small intestine	0.572 ± 0.045	0.586 ± 0.057	0.582 ± 0.063	0.597 ± 0.068	0.223 ± 0.021	0.228 ± 0.019	0.223 ± 0.017	0.223 ± 0.025
Lungs	1.435 ± 0.066	1.441 ± 0.059	1.463 ± 0.065	1.470 ± 0.078	0.381 ± 0.025	0.561 ± 0.028	0.559 ± 0.031	0.549 ± 0.032
Kidney	0.975 ± 0.053	0.967 ± 0.059	0.968 ± 0.062	0.948 ± 0.058	0.336 ± 0.015	0.346 ± 0.017	0.351 ± 0.016	0.313 ± 0.015
Epididymis	0.615 ± 0.056	0.603 ± 0.045	0.625 ± 0.038	0.620 ± 0.047	0.239 ± 0.013	0.235 ± 0.009	0.239 ± 0.010	0.232 ± 0.012
Vas deferens	0.125 ± 0.011	0.129 ± 0.009	0.131 ± 0.008	0.132 ± 0.009	0.049 ± 0.003	0.050 ± 0.005	0.050 ± 0.004	0.049 ± 0.006
Prostate	0.553 ± 0.071	0.547 ± 0.053	0.569 ± 0.064	0.565 ± 0.056	0.215 ± 0.011	0.213 ± 0.009	0.218 ± 0.013	0.211 ± 0.012
Testicle	1.618 ± 0.072	1.627 ± 0.068	1.614 ± 0.078	1.637 ± 0.059	0.629 ± 0.032	0.632 ± 0.027	0.617 ± 0.031	0.610 ± 0.025
Seminal vesicle	0.467 ± 0.022	0.471 ± 0.017	0.478 ± 0.021	0.469 ± 0.019	0.182 ± 0.007	0.183 ± 0.010	0.183 ± 0.009	0.175 ± 0.013

Wistar rats (n = 10 per group) were administered EEZZ by daily gavage for 4 weeks. Data are expressed as mean ± SD.