Elimination of Cancer Stem-Like “Side Population” Cells in Hepatoma Cell Lines by Chinese Herbal Mixture “Tien-Hsien Liquid”

Table 1

Synergistic combination effects of THL and doxorubicin against Huh7 SP cells (using mutually nonexclusive model). At fixed dose of THL and various doses of doxorubicin, the CI values were all well below 1, indicating the synergistic combination effects. Inhibition (fraction affected) values ranged from 0 (no inhibition) to 1 (100% inhibition). The higher the dose of doxorubicin used, the more proportion of cell viability was inhibited.

Mutually non-exclusive CI for experimental values
THL (μg/mL)	Dox (nM)	Fraction affected	CI
65	250	0.636	0.582
65	500	0.665	0.656
65	1000	0.83	0.512
65	2000	0.91	0.455