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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 623753, 10 pages
Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder
1Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
2The 4th Ward of Psychiatry Department, The 261th Hospital of the People's Liberation Army, Beijing 100094, China
3Clinical Laboratory, The 261th Hospital of the People's Liberation Army, Beijing 100094, China
Received 23 August 2012; Revised 5 November 2012; Accepted 20 November 2012
Academic Editor: Yao Tong
Copyright © 2012 Li-Ming Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- B. Bandelow, J. Zohar, E. Hollander et al., “World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders—first revision,” World Journal of Biological Psychiatry, vol. 9, no. 4, pp. 248–312, 2008.
- W. Berger, M. V. Mendlowicz, C. Marques-Portella et al., “Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: a systematic review,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 33, no. 2, pp. 169–180, 2009.
- D. J. Stein, J. Ipser, and N. McAnda, “Pharmacotherapy of posttraumatic stress disorder: a review of meta-analyses and treatment guidelines,” CNS Spectrums, vol. 14, no. 1, pp. 25–31, 2009.
- L. C. Pratchett, K. Daly, L. M. Bierer, and R. Yehuda, “New approaches to combining pharmacotherapy and psychotherapy for posttraumatic stress disorder,” Expert Opinion on Pharmacotherapy, vol. 12, no. 15, pp. 2339–2354, 2011.
- F. Corchs, D. J. Nutt, S. Hood, and M. Bernik, “Serotonin and sensitivity to trauma-related exposure in selective serotonin reuptake inhibitors-recovered posttraumatic stress disorder,” Biological Psychiatry, vol. 66, no. 1, pp. 17–24, 2009.
- J. H. Krystal and A. Neumeister, “Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience,” Brain Research, vol. 1293, pp. 13–23, 2009.
- M. Grah, M. Mihanović, P. Svrdlin, S. V. Pisk, and B. Restek-Petrović, “Serotonin and cortisol as suicidogenic factors in patients with PTSD,” Collegium Antropologicum, vol. 34, no. 4, pp. 1433–1439, 2010.
- T. A. Mellman, T. Alim, D. D. Brown et al., “Serotonin polymorphisms and posttraumatic stress disorder in a trauma exposed African American population,” Depression and Anxiety, vol. 26, no. 11, pp. 993–997, 2009.
- J. H. Krystal, E. Webb, N. L. Cooney et al., “Serotonergic and noradrenergic dysregulation in alcoholism: m-chlorophenylpiperazine and yohimbine effects in recently detoxified alcoholics and healthy comparison subjects,” American Journal of Psychiatry, vol. 153, no. 1, pp. 83–92, 1996.
- L. H. Price, R. T. Malison, C. J. McDougle, E. F. McCance-Katz, K. R. Owen, and G. R. Heninver, “Neurobiology of tryptophan depletion in depression: effects of m-chlorophenylpiperazine (mCPP),” Neuropsychopharmacology, vol. 17, no. 5, pp. 342–350, 1997.
- D. Britvić, D. Glučina, V. Antičevič et al., “Long-term improvement in coping skills following multimodal treatment in war veterans with chronic PTSD,” International Journal of Group Psychotherapy, vol. 62, no. 3, pp. 418–435, 2012.
- F. J. Stoddard, R. Luthra, E. A. Sorrentino et al., “A randomized controlled trial of sertraline to prevent posttraumatic stress disorder in burned children,” Journal of Child and Adolescent Psychopharmacology, vol. 21, no. 5, pp. 469–477, 2011.
- L. N. Ravindran and M. B. Stein, “Pharmacotherapy of post-traumatic stress disorder,” Current Topics in Behavioral Neurosciences, vol. 2, pp. 505–525, 2010.
- R. B. Hidalgo and J. R. T. Davidson, “Selective serotonin reuptake inhibitors in post-traumatic stress disorder,” Journal of Psychopharmacology, vol. 14, no. 1, pp. 70–76, 2000.
- M. B. Stein, N. A. Kline, and J. L. Matloff, “Adjunctive olanzapine for SSRI-resistant combat-related PTSD: a double-blind, placebo-controlled study,” American Journal of Psychiatry, vol. 159, no. 10, pp. 1777–1779, 2002.
- J. Zohar, D. Amital, C. Miodownik et al., “Double-blind placebo-controlled pilot study of sertraline in military veterans with posttraumatic stress disorder,” Journal of Clinical Psychopharmacology, vol. 22, no. 2, pp. 190–195, 2002.
- I. L. Petrakis, E. Ralevski, N. Desai et al., “Noradrenergic vs serotonergic antidepressant with or without naltrexone for veterans with PTSD and comorbid alcohol dependence,” Neuropsychopharmacology, vol. 37, no. 4, pp. 996–1004, 2012.
- H. N. Wang, Y. Peng, Q. R. Tan et al., “Free and Easy Wanderer Plus (FEWP), a polyherbal preparation, ameliorates PTSD-like behavior and cognitive impairments in stressed rats,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 33, no. 8, pp. 1458–1463, 2009.
- N. Sinclair-Lian, M. Hollifield, M. Menache, T. Warner, J. Viscaya, and R. Hammerschlag, “Developing a Traditional Chinese Medicine diagnostic structure for post-traumatic stress disorder,” Journal of Alternative and Complementary Medicine, vol. 12, no. 1, pp. 45–57, 2006.
- Z. J. Zhang, “Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders,” Life Sciences, vol. 75, no. 14, pp. 1659–1699, 2004.
- X. Xia, G. Cheng, Y. Pan, Z. H. Xia, and L. D. Kong, “Behavioral, neurochemical and neuroendocrine effects of the ethanolic extract from Curcuma longa L. in the mouse forced swimming test,” Journal of Ethnopharmacology, vol. 110, no. 2, pp. 356–363, 2007.
- C. Xu, L. Luo, and R. X. Tan, “Antidepressant effect of three traditional Chinese medicines in the learned helplessness model,” Journal of Ethnopharmacology, vol. 91, no. 2-3, pp. 345–349, 2004.
- H. K. Wang, “The therapeutic potential of flavonoids,” Expert Opinion on Investigational Drugs, vol. 9, no. 9, pp. 2103–2119, 2000.
- A. K. Jäger and L. Saaby, “Flavonoids and the CNS,” Molecules, vol. 16, no. 2, pp. 1471–1485, 2011.
- L. An, Y. Z. Zhang, N. J. Yu et al., “Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang,” Pharmacology Biochemistry and Behavior, vol. 89, no. 4, pp. 572–580, 2008.
- L. An, Y. Z. Zhang, N. J. Yu et al., “The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 32, no. 6, pp. 1484–1490, 2008.
- L. An, Y.-Z. Zhang, X. M. Liu et al., “Total flavonoids extracted from xiaobuxin-tang on the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 367619, 7 pages, 2011.
- Institute of Laboratory Animal Resources, Guide for the Care and Use of Laboratory Animals, Commission on Life Sciences, National Research Council, National Academy Press, Washington, DC, USA, 1996.
- S. Li, Y. Murakami, M. Wang, K. Maeda, and K. Matsumoto, “The effects of chronic valproate and diazepam in a mouse model of posttraumatic stress disorder,” Pharmacology Biochemistry and Behavior, vol. 85, no. 2, pp. 324–331, 2006.
- D. Knox, C. J. Fitzpatrick, S. A. George, J. L. Abelson, and I. Liberzon, “Unconditioned freezing is enhanced in an appetitive context: implications for the contextual dependency of unconditioned fear,” Neurobiology of Learning and Memory, vol. 97, no. 4, pp. 386–392, 2012.
- T. Takahashi, S. Morinobu, Y. Iwamoto, and S. Yamawaki, “Effect of paroxetine on enhanced contextual fear induced by single prolonged stress in rats,” Psychopharmacology, vol. 189, no. 2, pp. 165–173, 2006.
- S. Yamamoto, S. Morinobu, S. Takei et al., “Single prolonged stress: toward an animal model of posttraumatic stress disorder,” Depression and Anxiety, vol. 26, no. 12, pp. 1110–1117, 2009.
- R. S. Pynoos, R. F. Ritzmann, A. M. Steinberg, A. Goenjian, and I. Prisecaru, “A behavioral animal model of posttraumatic stress disorder featuring repeated exposure to situational reminders,” Biological Psychiatry, vol. 39, no. 2, pp. 129–134, 1996.
- Y. Iwamoto, S. Morinobu, T. Takahashi, and S. Yamawaki, “Single prolonged stress increases contextual freezing and the expression of glycine transporter 1 and vesicle-associated membrane protein 2 mRNA in the hippocampus of rats,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 31, no. 3, pp. 642–651, 2007.
- K. Kohda, K. Harada, K. Kato et al., “Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model,” Neuroscience, vol. 148, no. 1, pp. 22–33, 2007.
- J. Ji and S. Maren, “Hippocampal involvement in contextual modulation of fear extinction,” Hippocampus, vol. 17, no. 9, pp. 749–758, 2007.
- K. A. Corcoran and S. Maren, “Hippocampal inactivation disrupts contextual retrieval of fear memory after extinction,” Journal of Neuroscience, vol. 21, no. 5, pp. 1720–1726, 2001.
- A. A. Walf and C. A. Frye, “The use of the elevated plus maze as an assay of anxiety-related behavior in rodents,” Nature Protocols, vol. 2, no. 2, pp. 322–328, 2007.
- S. Yamamoto, S. Morinobu, M. Fuchikami, A. Kurata, T. Kozuru, and S. Yamawaki, “Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD,” Neuropsychopharmacology, vol. 33, no. 9, pp. 2108–2116, 2008.
- S. Hashimoto, T. Inoue, and T. Koyama, “Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats,” European Journal of Pharmacology, vol. 378, no. 1, pp. 23–30, 1999.
- N. Pivac, D. Mück-Šeler, M. Šagud, and M. Jakovljević, “Platelet serotonergic markers in posttraumatic stress disorder,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 26, no. 6, pp. 1193–1198, 2002.
- J. W. Dalley and J. P. Roiser, “Dopamine, serotonin and impulsivity,” Neuroscience, vol. 215, no. 26, pp. 42–58, 2012.
- R. J. Lee, A. Gill, B. Chen, M. McCloskey, and E. F. Coccaro, “Modulation of central serotonin affects emotional information processing in impulsive aggressive personality disorder,” Journal of Clinical Psychopharmacology, vol. 32, no. 3, pp. 329–335, 2012.
- H. T. Wang, F. Han, and Y. X. Shi, “Activity of the 5-HT1A receptor is involved in the alteration of glucocorticoid receptor in hippocampus and corticotropin-releasing factor in hypothalamus in SPS rats,” International Journal of Molecular Medicine, vol. 24, no. 2, pp. 227–231, 2009.
- S. Maren and W. G. Holt, “Hippocampus and Pavlovian fear conditioning in rats: muscimol infusions into the ventral, but not dorsal, hippocampus impair the acquisition of conditional freezing to an auditory conditional stimulus,” Behavioral Neuroscience, vol. 118, no. 1, pp. 97–110, 2004.
- S. Takei, S. Morinobu, S. Yamamoto, M. Fuchikami, T. Matsumoto, and S. Yamawaki, “Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder,” Journal of Psychiatric Research, vol. 45, no. 4, pp. 460–468, 2011.
- W. E. Müller, “Current St. John's wort research from mode of action to clinical efficacy,” Pharmacological Research, vol. 47, no. 2, pp. 101–109, 2003.