Protective Effect of Proanthocyanidin against Diabetic Oxidative Stress

Table 5

Hepatic biomarkers associated with oxidative stress in mouse model of type 2 diabetes.

Group	Dose; (mg/kg B.W./day)	TBARS; (nmol/mg protein)	ROS generation (%)	GSH; (μmol/mg protein)	GSSG; (μmol/mg protein)	GSH/GSSG
m/m	—	0.63 ± 0.07^a	100.3 ± 9.3^c	6.63 ± 0.36^a	4.65 ± 0.52	1.49 ± 0.12^c
db/db
Vehicle	—	1.18 ± 0.20	248.2 ± 30.3	4.91 ± 0.56	5.67 ± 0.57	0.86 ± 0.03
Polymers	10	1.11 ± 0.12	206.5 ± 15.7	4.63 ± 0.22	5.45 ± 0.24	0.85 ± 0.02
Oligomers	10	0.71 ± 0.07^a	185.1 ± 12.3	4.07 ± 0.36	3.76 ± 0.31^a	0.98 ± 0.05^b

The results are expressed as the mean ± SEM. Significance: ^a𝑃<0.05, ^b𝑃<0.01, ^c𝑃<0.001 versus db/db mice treated with vehicle.