The anti-inflammatory mechanisms of the three interventions used in the present study might be as follows: (1) VNS directly activates the cholinergic anti-inflammatory pathway via stimulating efferent vagus nerve. (2) ta-VNS evoked the activity of the auricular branch of vagus nerve (ABVN). The activated signals ascending within afferent vagus nerve are transmitted to the nucleus tractus solitarius. The integrated output is carried by the efferent vagus nerve to inhibit inflammatory responses. (3) TEAS on ST36 activates the somatic fiber endings of the skin around ST36 point, sending signals to the spinal cord via somatic sensory nerve fibers. The nerve impulses were relayed and integrated by NTS by the secondary order neurons in the spinal cord, and the cholinergic anti-inflammatory pathways are activated by the increased efferent vagal output.