- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 627023, 10 pages
Transcutaneous Auricular Vagus Nerve Stimulation Protects Endotoxemic Rat from Lipopolysaccharide-Induced Inflammation
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, 16 Nanxiaojie Street, Dongzhimen Nei, Beijing 100700, China
Received 21 August 2012; Revised 5 December 2012; Accepted 6 December 2012
Academic Editor: Ying Xia
Copyright © 2012 Yu Xue Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- K. J. Tracey, “The inflammatory reflex,” Nature, vol. 420, no. 6917, pp. 853–859, 2002.
- K. J. Tracey, Y. Fong, D. G. Hesse et al., “Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia,” Nature, vol. 330, no. 6149, pp. 662–664, 1987.
- K. J. Tracey, B. Beutler, and S. F. Lowry, “Shock and tissue injury induced by recombinant human cachectin,” Science, vol. 234, no. 4775, pp. 470–474, 1986.
- V. A. Pavlov and K. J. Tracey, “The cholinergic anti-inflammatory pathway,” Brain, Behavior, and Immunity, vol. 19, no. 6, pp. 493–499, 2005.
- J. M. Huston, M. Gallowitsch-Puerta, M. Ochani et al., “Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis,” Critical Care Medicine, vol. 35, no. 12, pp. 2762–2768, 2007.
- L. V. Borovikova, S. Ivanova, M. Zhang et al., “Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin,” Nature, vol. 405, no. 6785, pp. 458–462, 2000.
- J. Huang, Y. Wang, D. Jiang, J. Zhou, and X. Huang, “The sympathetic-vagal balance against endotoxemia,” Journal of Neural Transmission, vol. 117, no. 6, pp. 729–735, 2010.
- D. J. van Westerloo, I. A. J. Giebelen, J. C. M. Meijers et al., “Vagus nerve stimulation inhibits activation of coagulation and fibrinolysis during endotoxemia in rats,” Journal of Thrombosis and Haemostasis, vol. 4, no. 9, pp. 1997–2002, 2006.
- T. R. Bernik, S. G. Friedman, M. Ochani et al., “Pharmacological stimulation of the cholinergic antiinflammatory pathway,” Journal of Experimental Medicine, vol. 195, no. 6, pp. 781–788, 2002.
- S. Guarini, D. Altavilla, M. M. Cainazzo et al., “Efferent vagal fibre stimulation blunts nuclear factor-κB activation and protects against hypovolemic hemorrhagic shock,” Circulation, vol. 107, no. 8, pp. 1189–1194, 2003.
- M. Li, C. Zheng, T. Sato, T. Kawada, M. Sugimachi, and K. Sunagawa, “Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats,” Circulation, vol. 109, no. 1, pp. 120–124, 2004.
- C. Mioni, C. Bazzani, D. Giuliani et al., “Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia/reperfusion injury in rats,” Critical Care Medicine, vol. 33, no. 11, pp. 2621–2628, 2005.
- S. T. Huang, G. Y. Chen, H. M. Lo, J. G. Lin, Y. S. Lee, and C. D. Kuo, “Increase in the vagal modulation by acupuncture at Neiguan point in the healthy subjects,” American Journal of Chinese Medicine, vol. 33, no. 1, pp. 157–164, 2005.
- Z. Li, K. Jiao, M. Chen, and C. Wang, “Effect of magnitopuncture on sympathetic and parasympathetic nerve activities in healthy driver—assessment by power spectrum analysis of heart rate variability,” European Journal of Applied Physiology, vol. 88, no. 4-5, pp. 404–410, 2003.
- J. H. Wu, H. Y. Chen, Y. J. Chang et al., “Study of autonomic nervous activity of night shift workers treated with laser acupuncture,” Photomedicine and Laser Surgery, vol. 27, no. 2, pp. 273–279, 2009.
- C. C. Hsu, C. S. Weng, T. S. Liu, Y. S. Tsai, and Y. H. Chang, “Effects of electrical acupuncture on acupoint BL15 evaluated in terms of heart rate variability, pulse rate variability and skin conductance response,” American Journal of Chinese Medicine, vol. 34, no. 1, pp. 23–36, 2006.
- K. Imai and H. Kitakoji, “Comparison of transient heart rate reduction associated with acupuncture stimulation in supine and sitting subjects,” Acupuncture in Medicine, vol. 21, no. 4, pp. 133–137, 2003.
- W. He, P. J. Rong, L. Li, H. Ben, B. Zhu, and G. Litscher, “Auricular acupuncture may suppress epileptic seizures via activating the parasympathetic nervous system: a hypothesis based on innovative methods,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 615476, 5 pages, 2012.
- L. Bertók, “Endotoxins and endocrine system,” Domestic Animal Endocrinology, vol. 15, no. 5, pp. 305–308, 1998.
- H. Wang, M. Yu, M. Ochani et al., “Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation,” Nature, vol. 421, no. 6921, pp. 384–388, 2003.
- W. Deng, X. Wang, J. Xiao et al., “Loss of regulator of G protein signaling 5 exacerbates obesity, hepatic steatosis, inflammation and insulin resistance,” PLoS ONE, vol. 7, no. 1, Article ID e30256, 2012.
- O. J. D'Cruz and F. M. Uckun, “Preclinical evaluation of a dual-acting microbicidal prodrug WHI-07 in combination with vanadocene dithiocarbamate in the female reproductive tract of rabbit, pig, and cat,” Toxicologic Pathology, vol. 35, no. 7, pp. 910–927, 2007.
- J. M. Huston, M. Ochani, M. Rosas-Ballina et al., “Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis,” Journal of Experimental Medicine, vol. 203, no. 7, pp. 1623–1628, 2006.
- T. R. Bernik, S. G. Friedman, M. Ochani et al., “Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion,” Journal of Vascular Surgery, vol. 36, no. 6, pp. 1231–1236, 2002.
- D. Altavilla, S. Guarini, A. Bitto et al., “Activation of the cholinergic anti-inflammatory pathway reduces NF-κB activation, blunts TNF-α production, and protects against splanchnic artery occlusion shock,” Shock, vol. 25, no. 5, pp. 500–506, 2006.
- P. A. Bauerle and D. Baltmore, “NF-κB: ten years after,” Cell, vol. 87, no. 1, pp. 13–20, 1996.
- M. L. Schmitz and P. A. Bauerle, “Multi step activation of NF-κB/rel transcriptional factors,” Immunobiology, vol. 193, no. 2–4, pp. 116–127, 1995.
- R. Schreck, P. Rieber, and P. A. Baeuerle, “Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1,” EMBO Journal, vol. 10, no. 8, pp. 2247–2258, 1991.
- F. Squadrito, D. Altavilla, B. Deodato et al., “Early activation of transcription factor NF-κB in splanchnic artery occlusion shock,” in Proceedings of the 5th World Congress on Trauma Shock Inflammation and Sepsis Pathophysiology Immune Consequences and Therapy, E. Faist, Ed., pp. 389–394, Monduzzi, Munich, Germany, March 2000.
- C. O'Mahony, “Loss of vagal anti-inflammatory effect: in vivo visualization and adoptive transfer,” American Journal of Physiology, vol. 297, no. 4, pp. R1118–R1126, 2009.
- X. M. Song, J. G. Li, Y. L. Wang et al., “The protective effect of the cholinergic anti-inflammatory pathway against septic shock in rats,” Shock, vol. 30, no. 4, pp. 468–472, 2008.
- K. Imai, H. Ariga, C. Chen, C. Mantyh, T. N. Pappas, and T. Takahashi, “Effects of electroacupuncture on gastric motility and heart rate variability in conscious rats,” Autonomic Neuroscience: Basic and Clinical, vol. 138, no. 1-2, pp. 91–98, 2008.
- H. Ouyang, J. Yin, Z. Wang, P. J. Pasricha, and J. D. Z. Chen, “Electroacupuncture accelerates gastric emptying in association with changes in vagal activity,” American Journal of Physiology, vol. 282, no. 2, pp. G390–G396, 2002.
- Q. Wang, F. Wang, X. Li et al., “Electroacupuncture pretreatment attenuates cerebral ischemic injury through α7 nicotinic acetylcholine receptor-mediated inhibition of high-mobility group box 1 release in rats,” Journal of Neuroinflammation, vol. 9, article 24, 2012.
- X. Y. Gao, Y. H. Li, K. Liu et al., “Acupuncture-like stimulation at auricular point Heart evokes cardiovascular inhibition via activating the cardiac-related neurons in the nucleus tractus solitarius,” Brain Research, vol. 1397, pp. 19–27, 2011.
- X. Y. Gao, S. P. Zhang, B. Zhu, and H. Q. Zhang, “Investigation of specificity of auricular acupuncture points in regulation of autonomic function in anesthetized rats,” Autonomic Neuroscience, vol. 138, no. 1-2, pp. 50–56, 2008.
- I. Tekdemir, A. Asian, and A. Elhan, “A clinico-anatomic study of the auricular branch of the vagus nerve and Arnold's ear-cough reflex,” Surgical and Radiologic Anatomy, vol. 20, no. 4, pp. 253–257, 1998.
- D. Gupta, S. Verma, and S. K. Vishwakarma, “Anatomic basis of Arnold's ear-cough reflex,” Surgical and Radiologic Anatomy, vol. 8, no. 4, pp. 217–220, 1986.
- D. Engel, “The gastroauricular phenomenon and related vagus reflexes,” Archiv fur Psychiatrie und Nervenkrankheiten, vol. 227, no. 3, pp. 271–277, 1979.
- V. A. Pavlov, H. Wang, C. J. Czura, S. G. Friedman, and K. J. Tracey, “The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation,” Molecular Medicine, vol. 9, no. 5–8, pp. 125–134, 2003.