Table 5: Adverse Events.

Ads/IDComparisonTreatment group ( )Control group ( )RR95% CI

Loss of followup
Guan 2010 [22]Xuezhikang versus simvastatin16 (72)15 (64)0.95
CCSPS 2005 [4]Xuezhikang and conventional therapy versus placebo and conventional therapy37 (2441)28 (2429)1.31
Ma and Teng 2005 [29]Xuezhikang and conventional therapy versus conventional therapy1 (29)No report

Intestinal disturbance
Guan 2010 [22]Xuezhikang versus simvastatin5 (72)2 (64)2.22
Ma and Teng 2005 [29]Xuezhikang and conventional therapy versus conventional therapy2 (29)No report
Wang et al. 2004 [6]Xuezhikang and conventional therapy versus conventional therapy2 (26)No report
Jiang and Cai 2001 [25]Xuezhikang and conventional therapy versus simvastatin and conventional therapy0 (30)1 (45)0.49
Shang 2007 [31]Xuezhikang and conventional therapy versus atorvastatin and conventional therapyNo report1 (65)
Wang and Xiao 2000 [32]Xuezhikang and aspirin versus inositol nicotinate and aspirin5 (65)2 (57)2.19

Headache
Jiang and Cai 2001 [25]Xuezhikang and conventional therapy versus simvastatin and conventional therapy1 (30)0 (45)4.45

Dizziness
Guan 2010 [22]Xuezhikang and conventional therapy versus simvastatin and conventional therapy0 (72)10 (64)0.04
Jiang and Cai 2001 [25]Xuezhikang and conventional therapy versus simvastatin and conventional therapy1 (30)1 (45)1.5
Overall (REM, I2 = 72%) 0.26

Skin itech
Guan 2010 [22]Xuezhikang versus simvastatin0 (72)3 (64)0.13
Wang and Xiao 2000 [32]Xuezhikang and aspirin versus inositol nicotinate and aspirin0 (65)3 (57)0.13

Sexual dysfunction
CCSPS 2005 [4]Xuezhikang and conventional therapy versus placebo and conventional therapy0 (1996)5 (1990)0.09

High serum ALT
CCSPS 2005 [4]Xuezhikang and conventional therapy versus placebo and conventional therapy15 (2441)22 (2429)0.68
Lou et al. 2008 [28]Xuezhikang and conventional therapy versus simvastatin and conventional therapyNo report1 (41)

High serum CK
CCSPS 2005 [4]Xuezhikang and conventional therapy versus placebo and conventional therapy0 (2441)3 (2429)0.14

High serum CR
CCSPS 2005 [4]Xuezhikang and conventional therapy versus placebo and conventional therapy104 (2441)89 (2429)1.16
High BUN
CCSPS 2005 [4]Xuezhikang and conventional therapy versus placebo and conventional therapy124 (2441)131 (2429)0.94