Attenuation of TRPV1 and TRPV4 Expression and Function in Mouse Inflammatory Pain Models Using Electroacupuncture
Figure 4
Electrophysiological properties of AP (action potential) and TRPV1-mediated inward currents in the Con (control), CFA (complete Freund’s adjuvant), and EA (electroacupuncture) groups. (a) The AP threshold was more negative in the CFA group than in the control group. EA attenuated neuron excitability by reversing the AP threshold to a positive membrane potential. (b) CFA-induced inflammation decreased both the rising and falling times compared with the control group. EA treatment decreased the neuron excitability to the control level. (c) The capsaicin- (cap-) induced inward current was increased in CFA-treated DRG neurons compared with the control group. This was reversed by EA manipulation.
