A Herbal Composition of Semen Hoveniae, Radix Puerariae, and Fructus Schisandrae Shows Potent Protective Effects on Acute Alcoholic Intoxication in Rodent Models
Table 3
Effects of SRFE on ADH and ALDH levels in acutely inebriated rats.
Groups
Doses (g/kg)
Ethanol (g/kg)
Stomach
Small intestine
Liver
ADH (U/g prot)
ALDH (mol/L)
ADH (U/g prot)
ALDH (mol/L)
ADH (U/g prot)
ALDH (mol/L)
Control
—
0.00
0.95 ± 0.03
0.39 ± 0.01
2.75 ± 0.20
1.65 ± 0.06
7.56 ± 0.33
6.31 ± 0.08
SRFE control
0.16
0.00
1.10 ± 0.05#
0.42 ± 0.01
3.12 ± 0.14
1.73 ± 0.11
9.56 ± 0.34##
8.10 ± 0.10##
Model
—
4.50
0.85 ± 0.07
0.36 ± 0.02#
2.49 ± 0.26
0.46 ± 0.08##
8.87 ± 0.57
7.92 ± 0.33##
SRFE
0.04
4.50
0.97 ± 0.05
0.38 ± 0.01
2.75 ± 0.27
0.45 ± 0.05
8.92 ± 0.45
7.91 ± 0.21
0.08
4.50
0.97 ± 0.05
0.41± 0.02*
2.91 ± 0.22
0.57 ± 0.10
9.29 ± 0.53
8.11 ± 0.28
0.16
4.50
1.07± 0.05*
0.41± 0.01*
3.27 ± 0.22*
1.19 ± 0.14**
9.77 ± 0.35
8.27 ± 0.26
HWJZ
0.25
4.50
0.97 ± 0.06
0.36 ± 0.01
2.81 ± 0.22
0.80 ± 0.14
10.47 ± 0.50*
9.95 ± 0.24**
SRFE: Semen Hoveniae, Radix Puerariae, and Fructus Schisandrae extract; HWJZ: Hai-Wang-Jin-Zun tablet; ADH: ethanol dehydrogenase; ALDH: acetaldehyde dehydrogenase. Means ± S.E.M., . , versus control; , versus model.