Mapuche Herbal Medicine Inhibits Blood Platelet Aggregation

Table 3

Seven plant species that showed inhibitory effect in sheep blood were subsequently tested in human blood. The agonists are ADP (5.0 μM) and collagen (2.0 μg/mL) and the obtained aggregations are shown in percent. Extracts are tested in 0.1 mg/mL end concentrations. The aggregation is shown for both extract and vehicle control. If the extract aggregation is 20% lower than that of the vehicle control inhibition is observed.

Plant	Extract	Agonist	% Aggregation (extract)	% Aggregation (vehicle control)	% Inhibition	Inhibition
Amomyrtus luma (leaf)	DCM : MeOH 1 : 1	ADP	57	73	22	Yes
		Collagen	62	87	29	Yes
	MeOH	ADP	66	70	6	No
		Collagen	68	70	3	No
	H2O	ADP	66	69	4	No
		Collagen	60	76	21	Yes
Anthoxanthum utriculatum (leaf)	MeOH	ADP	63	64	2	No
		Collagen	63	68	7	No
Blechnum chilense (leaf)	DCM : MeOH 1 : 1	ADP	73	77	5	No
		Collagen	74	73	−1	No
	MeOH	ADP	60	83	28	Yes
		Collagen	61	86	29	Yes
Cestrum parqui (leaf)	DCM : MeOH 1 : 1	ADP	61	84	27	Yes
		Collagen	67	84	20	Yes
	MeOH	ADP	70	70	0	No
		Collagen	71	71	0	No
	H2O	ADP	74	71	−4	No
		Collagen	64	68	6	No
Lomatia ferruginea (leaf)	DCM : MeOH 1 : 1	ADP	72	72	0	No
		Collagen	73	71	−3	No
Luma apiculata (leaf)	MeOH	ADP	70	67	−4	No
		Collagen	65	71	8	No
	H2O	ADP	46	84	45	Yes
		Collagen	54	85	36	Yes
Pseudopanax laetevirens (leaf)	DCM : MeOH 1 : 1	ADP	69	72	4	No
		Collagen	66	72	8	No
	MeOH	ADP	69	72	4	No
		Collagen	69	76	9	No