Research Article

Effect of a New Prokinetic Agent DA-9701 Formulated with Corydalis Tuber and Pharbitidis Semen on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes

Table 2

values for the inhibition of CYP2D6-catalyzed bufuralol 1′-hydroxylation activity by DA-9701, Corydalis tuber extract, and quinidine in pooled human liver microsomes, H161.

Substances Inhibition mode

DA-97016.3 g/mLNoncompetitive
Corydalis tuber extract3.7 g/mLCompetitive
Quinidine0.038 MNoncompetitive